GDFE can regulate the polarization state of macrophages and improve the healing ability of diabetic wounds

With the prevalence of diabetes, chronic wound healing, a major complication, has become a global health problem with rising medical service costs and reduced quality of life for patients.

The continuous inflammatory state seriously affects the transition process of wound healing from inflammation to cell proliferation, causing macrophages (key regulators) to fail to respond, and impairing the polarization of macrophages from inflammatory (M1) to anti-inflammatory (M2) State transition.

Recently, Mao Cong and Lin Cai of Wenzhou Medical University, and Lei Bo of Xi’an Jiaotong University have designed a new type of hydrogel (GDFE) using F127-ε-polylysine (EPL) and polydopamine modified graphene oxide.

[Article Highlights]

1.

As shown in Figure 1, polydopamine modifies graphene oxide through an amide bond to form modified graphene oxide GD, and GD reacts with the bond F127-EPL to form a hydrogel (GDFE) through the Schiff base reaction.

Figure 1 Schematic diagram of the synthesis and application of GDFE hydrogel

2.

In the study, GDFE hydrogel was incubated with RAW264.

　　Figure 2 Morphological changes and M2 phenotype polarization of RAW264.

　　3.

　　In in vivo experiments, GDFE hydrogel-treated wounds can be made into sections for anti-inflammatory and macrophage activation characterization (Figure 3).

　　Figure 3 GDFE hydrogel can relieve inflammation and stimulate M2 polarization of macrophages in diabetic wounds