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    Home > Active Ingredient News > Drugs Articles > Gene editing obtains high-quality human vascular cells

    Gene editing obtains high-quality human vascular cells

    • Last Update: 2021-02-20
    • Source: Internet
    • Author: User
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    The Liu Guanghui Research Group of the Institute of Biophysics of the Chinese Academy of Sciences, the Tang Fufu Research Group of Peking University and the Qu Jing Research Group of the Institute of Zoology of the Chinese Academy of Sciences have produced the world's first genetically enhanced human vascular cells by targeting and editing a single longevity gene. Compared with wild vascular cells, these vascular cells can not only promote vascular repair and regeneration more efficiently, but also effectively resist tumor-like transformation of cells, which provides an important solution for safe and effective clinical cell therapy. The study was published recently in the international authoritative journal Cell Stem Cells., FOXO3 is an important human longevity gene, which is closely related to delaying cell aging, resisting external stress and enhancing cardiovascular stability. Using relevant gene editing techniques, the researchers found that when FOXO3 genetically enhanced human embryonic stem cells were directed to differentiate into vascular endothragm cells (vascular endometrials), vascular smooth muscle cells (vascular membranes) and interstitial cells (extravascular membranes), all three vascular cells showed greater self-renewal, resistance to oxidative damage and delayed cell aging than wild cells. "More importantly, the targeting of genetically enhanced human vascular cells to isotic sites in animal models can effectively promote the regeneration of damaged blood vessels and rapidly restore blood flow at isoemia sites, demonstrating that these cells have significantly better vascular repair capabilities than wild cells." Liu Guanghui said.to verify the cell's safety, the researchers imported a variety of cancer-causing genes into wild and genetically enhanced stem cells and found that genetically enhanced stem cells were also effective in resisting cancer-induced cell malignant transformation.Liu Guanghui, , said the study was the first to use gene editing technology to enhance the function of human blood vessel cells, and conceptually proved the feasibility of using gene editing strategies to obtain high-quality and safe human vascular cell grafts. In addition, the study made it possible to scale and standardize the preparation of high-quality and safe human cell therapy materials, providing a promising option for regenerative medicine. (Health Journal)
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