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    Home > Biochemistry News > Biotechnology News > Gene return: Bacteria that produce antibiotics provide resistant genes to germs.

    Gene return: Bacteria that produce antibiotics provide resistant genes to germs.

    • Last Update: 2020-08-30
    • Source: Internet
    • Author: User
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    Where do the genes that make drug-resistant bacteria come from when antibiotic abuse leads to their emergence and widespread spread? Danish researchers have confirmed for the first time a long-standing scientific hypothesis that it is the bacteria that produce antibiotics that provide the resistant genes to germs.
    Denmark Technical University said in a press release that its researchers compared the genetic sequences of some common bacteria with those of a variety of line bacteria and found that the drug-resistant genes were very similar, some of them identical, suggesting that the bacteria obtained them from the line bacteria.
    is a widely distributed class of bacteria, mainly found in the soil, can produce a variety of antibiotics, human currently used antibiotic drugs at least three quarters from the line bacteria.
    that the scientific community has previously found that the bacteria themselves carry antibiotic-resistant genes, the new study is the first to confirm that the bacteria's resistance genes come from the line bacteria.
    exchange between similar bacteria is common, but these bacteria and line bacteria are very different, relatives are far away, how do they achieve gene transfer? The researchers suggest that this may involve a previously unknown transfer mechanism, which they call "gene return."
    contaminated soil with medical waste or farm waste, giving germs access to line bacteria.
    bacteria inject their DNA (deoxyrifunucleic acid) into the line bacteria through a bacterial joining process, recombining with DNA containing drug-resistant genes in the line bacteria's genome.
    dies, recombinant DNA enters the surrounding environment, and the bacteria's DNA can act as a "glue" to return to the bacteria's genome with drug-resistant genes.
    researchers report in the new issue of the British journal Nature Communications that they have experimentally demonstrated that this gene transfer may indeed occur.
    they believe that while there is no way to stop gene transfer, understanding which drug-resistant genes the bacteria may carry could help doctors develop more targeted antibiotic therapies and develop new antibiotics to overcome germ resistance.
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