Genetic alterations explain chemotherapy resistance in germ cell cancer

Extra copies of DNA segments partly explain why germ cell cancers are not sensitive to chemotherapy, a new study suggests

Germ cell cancer is caused by defects in the development of eggs in girls and sperm in boys

In order to develop new treatments, it is important to understand what causes insensitivity to cisplatin

extra copies in DNA

First, the scientists analyzed the entire DNA of germ cell cancer cells in the lab: live cells desensitized to cisplatin

Next, the researchers looked at DNA from male germ cell cancer patients of different ages, including before and after cisplatin treatment, to see how often the changes in 3p25.

Clinical Value

To further investigate the impact of the extra 3p25.

"Our research is still in the early stages, but in the future our findings could help identify patients with germ cell cancer who are at high risk for resistance to cisplatin chemotherapy at an early stage

Chromosome 3p25.