The ABO gene contains three main alleles, which encode different antigens, namely A, B, and O.
Each antigen can determine the blood type of each person.
In previous studies, researchers focused on determining ABO The relationship between blood type and disease risk
Recently, a research report entitled "Characterization of the human ABO genotypes and their association to common inflammatory and cardiovascular diseases in the UK Biobank" was published in the international journal American Journal of Hematology, from Uppsala University and other institutions.
Scientists have shown through research that a person’s blood type can be determined based on genetic tests rather than traditional blood tests, or they can better understand their risk of cardiovascular disease; if a patient has two A, B, or AB The risk of disease may be twice that of individuals with O gene mutations
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Researcher Julia Hoglund said that the huge difference in the risk of a person’s thrombosis depends on whether they have one or two gene mutations in the A, AB, or B blood type.
In short, if they carry two A or B gene mutations instead of One, then the risk of blood clots will be doubled
A person can have one of four blood types, and a person's blood type is also very important to him, such as during blood transfusions
And recent studies have shown that blood type plays a key role in how a person is infected by viruses and bacteria, and even plays a key role in the occurrence of cardiovascular disease and cancer
The results of this study indicate that a person’s genetic mutations inherited from their parents may affect their risk of disease.
In-depth analysis of population genetics information
Similar to the results of previous studies, in this study, the researchers found that individuals with O blood type have the lowest risk of cardiovascular disease, such as blood clots, compared to individuals with other blood types
But by genetic analysis of blood types, rather than traditional blood analysis (that is, using antibody tests), researchers can determine which genetic mutations a person inherits from their parents; this may be important in identifying diseases.
Because individuals with type A blood may carry two A mutants or one A mutant and one O mutant
The results come from the regression analysis of all diseases, in which ABO blood type has a significant contribution to the correlation
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The researchers said that since both type A and type B cover up the O type gene, it cannot be detected in routine blood tests.
Gene mutations carried by a person's body play an important role in the development of cardiovascular disease.
If this is the standard method used for patients, it may greatly improve the ability of scientists to spot high-risk patients
Another finding of the study in this article is that researchers can see that the levels of multiple proteins in individuals with different blood types are also different.
The most obvious example of this is proteins that can help blood clot; individuals with the same blood type that increase the risk of thrombosis.
The level of proteins that are important for blood clotting may increase
The findings of this article show that by determining the blood type and blood type inheritance of patients as standards, researchers may be able to detect and start treatment of related diseases in the early stages of the disease, which may prevent or slow down the occurrence of serious complications in patients
In summary, the results of this study indicate that in the future, it may be necessary to incorporate ABO genotype information into the consultation and management of high-risk patients, instead of dividing patients into different blood types
Julia Höglund,Torgny Karlsson,Therese Johansson, et al.
Characterization of the human ABO genotypes and their association to common inflammatory and cardiovascular diseases in the UK Biobank, American Journal of Hematology (2021).