Genomic Diversity and Ancestral Information Analysis and PGG Population (Group Genomics- Communities)

On November 3, xu Shuhua of the Institute of Computational Biology of the Shanghai Institute of Life Sciences (Population Health) of the Chinese Academy of Sciences published online in the journal Nucleic Acid Research under the title PGG. Population for understanding domain diversity diversity and genetic ancestry of human.
the study analyzed genomic diversity and ancestral information from 356 human communities in 107 countries worldwide, and published an open-access database, PGG. Population (Group Genomics, Community).
PGG. Population is the only public database to analyze the genetic relationships and ancestral sources of human populations at the genomic level, and it is also the largest group genome database collected by the population, providing a platform for researchers, clinicians, and students and the public to understand the genetic background of different populations.
the formation of human ethnic diversity is a complex evolutionary process of migration, isolation, differentiation, re-contact and communication.
at the same time, long-term adaptation to specific environments may affect the diversity of specific traits and local regions of the genome.
relative, the diversity of the genome of a population largely determines its episotype diversity -- which is why ethnically specific epitotypes can be passed down from generation to generation.
therefore, to truly understand the differences in color, physique and disease and other traits of different ethnic groups, it is necessary to go back to the genome and trace the evolution of the population.
numerous large-scale international initiatives (such as the Human Haplotype Mapping Program and the Thousand Human Genome Project) and the various genome-wide correlation studies (GWAS) previously completed in China focus on common subject populations, while there is a lack of research on minority groups (mostly indigenous) in various regions.
some researchers have come to realize that confusion in one population study often finds the answer in another, such as comparing the genomes of people on the Qinghai-Tibet Plateau to understand why plain populations can't live on the plateau as comfortably as Tibetans.
experts say that this is the charm of diversity, but also the wealth that evolution has left us.
PGG. It is in this context that Population was built up.
researchers re-integrate and analyze the genomes of each population (including basic information such as geographic language attribution of populations, Y chromosomes and mitochondrial genealogy, intergroup kinship, group genetic structure, genetic mixing, and natural selection imprinting) by sequencing or collecting numerous human population genomic research data, and establishing a database to present the genome diversity and ancestral information of each population to the public in an openly accessible manner.
currently, the database includes genomic data from 7,122 individuals, covering 356 ethnic groups in 107 countries, each with its own "story".
the database is based on understanding the genomic diversity and genetic background of each population, and it is also of great academic significance and application value in other research fields.
there are more than 2,000 ethnic groups worldwide, and the database currently includes only one-half of the world's ethnic groups.
task force is collecting or generating more genomic data from different ethnic groups to reach a wider population, with a view to comprehensively exploring genetic and evolutionary issues such as the evolutionary history and natural selection of Asian populations, particularly in East and South-East Asia.
at the same time, the database can be used for reference and use in genetics, linguistics, physical anthropology, medicine and other industries, and applied to biomedical research in many fields.
in addition, researchers want a broader and deeper understanding of knowledge and information about the diversity of the human genome and the origin of populations through access to and access to the database.
research work has been supported by the Chinese Academy of Sciences' Strategic Leading Science and Technology Special (Class B), the National Natural Science Foundation's Major Research Program and the National Science Fund for Distinguished Young People, the Chinese Academy of Sciences Youth Promotion Association, the Shanghai Science and Technology Commission, etc., and supported by the National Center for Collaborative Innovation in Genetics and Development.
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