German research says an inhibitor can be used to fight the new coronavirus in a two-pronged way

BERLIN, Aug. 6 (Xinhua) -- Researchers at the Max Planck Institute for Biophysics in Germany have teamed up with their international counterparts to find an inhibitor that can work together to fight the new coronavirus, not only blocking the replication of the new coronavirus, but also enhancing the body's immune response to the new coronavirus. This research will help develop new anti-neoviral therapies.The researchers found in in-body cell experiments that when the new coronavirus infects human cells, it allows the cells to produce a substance called protease-like protease (PLpro), which not only participates in the replication process of the new coronavirus, but also hinders the body's immune system's response to the new coronavirus, the
bulletin said.
team has found an inhibitor called GRL-0617, which inhibits PLpro from functioning. Studies in bioinstructive, structural and functional aspects have shown that the use of this inhibitor can have two effects, not only hindering the replication of the new coronavirus, but also enhance the body's immune response to the new coronavirus.
new findings suggest that inhibiting PLpro is a promising anti-neovirus strategy, and hope to build on this by developing new therapies that could be used in clinical trials, the researchers said.