Geroscience: MT and inflammation are associated with poor physical function in older adults with comedies.

It is assumed that intestinal barrier dysfunction is the leading factor in two significant features of aging, inflammation and decreased body function.
It has been reported that in healthy older adults, rats, and invertebrates, there is an association between microbial transposing (MT) or its biomarkers (lipid polysaccharide binding protein-1(LBP-1), soluble differentiation clusters (sCDs)-14) and body function.
, however, it is not clear whether there is a combination, or whether clinical interventions aimed at reducing it through weight loss or exercise can change the link, the findings of which have been published online in Geroscience.
researchers measured inflammation, MT, and body function in 288 overweight/obese elderly patients with heart metabolic disease and self-reported movement restrictions, and participated in weight loss and lifestyle intervention studies.
showed a positive correlation between inflammatory cytokines and LBP-1 when age, sex, and body mass index were corrected during the baseline period.
the covariation, higher LTP-1 was closely related to poorer body function.
addition, even if the IL-6 level is included in the model, 400 m walking time (p s 0.003), short physical performance (p s 0.07) and IL-8 (p slt;0.001) are still positively related to LBP-1.
lifestyle interventions improved body mass and some functional measurements; however, MT and inflammation did not change.
, the results show that MT is closely related to inflammation and poor physical function in older adults with adhesive disorders.
intestinal barrier function does not appear to have improved as a result of the allocation of interventions, suggesting that other strategies are needed to address this inflammatory pathway in aging.
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