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    Home > Active Ingredient News > Infection > Geroscience: Persistent viral RNA shedding from SARS-CoV-2 is associated with delirium incidence and 6-month mortality in hospitalized COVID-19 patients

    Geroscience: Persistent viral RNA shedding from SARS-CoV-2 is associated with delirium incidence and 6-month mortality in hospitalized COVID-19 patients

    • Last Update: 2022-08-10
    • Source: Internet
    • Author: User
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    Background: The World Health Organization has declared that the novel coronavirus is the virus responsible for the 2019 (COVID-19) global outbreak of coronavirus disease that began in March 202 As of February 2022, COVID-19 has affected more than 429 million people worldwide and caused more than 9 million deat.


    Background: The World Health Organization has declared that the novel coronavirus is the virus responsible for the 2019 (COVID-19) global outbreak of coronavirus disease that began in March 202 As of February 2022, COVID-19 has affected more than 429 million people worldwide and caused more than 9 million deat.


    Assessment of persistent viral RNA shedding is one way to track recovery and long-term response to severe viral infecti.


    Objective: To further understand the ongoing clinical care of hospitalized patients with COVID-19 and to explore disease mechanisms, we sought to determine the prevalence and risk factors of persistent viral RNA shedding and to assess its association with delirium, a major neurological complication of acute COVID-1 ) and 6-month mortality in hospitalized patients with COVID-1

    Methods: We retrospectively assessed persistent viral shedding in Northwestern Medicine and Healthcare (NMHC) patients between March and August 202

    Methods: We retrospectively assessed persistent viral shedding in Northwestern Medicine and Healthcare (NMHC) patients between March and August 202

    RESULTS: Among 2518 hospitalized patients with 2019-nCoV confirmed by reverse transcription polymerase chain reaction (RT-PCR), 959 patients had repeated 2019-nCoV RT-PCR at least 14 days after the first positive test (RT-PC.


    RESULTS: Among 2518 hospitalized patients with 2019-nCoV confirmed by reverse transcription polymerase chain reaction (RT-PCR), 959 patients had repeated 2019-nCoV RT-PCR at least 14 days after the first positive test (RT-PC.


    Table 1 Long-term (confirmed > 14 days) viral RNA shedding model

    Table 2 Models of delirium (previously positive for confounding assessment methods) and acute brain dysfunction

    Table 2 Models of delirium (previously positive for confounding assessment methods) and acute brain dysfunction

    Table 3 Six-month mortality model

    Table 3 Six-month mortality model

    Conclusions: Persistent viral shedding frequently occurs in hospitalized patients with COVID-19 and is associated with increased in-hospital delirium and 6-month mortali.


    Conclusions: Persistent viral shedding frequently occurs in hospitalized patients with COVID-19 and is associated with increased in-hospital delirium and 6-month mortali.


    Original source: Batra A, Clark JR, Kang AK, et .
    Persistent viral RNA shedding of SARS-CoV-2 is associated with delirium incidence and six-month mortality in hospitalized COVID-19 patien.
    Geroscience 2022 May 11 Persistent viral RNA shedding of SARS-CoV-2 is associated with delirium incidence and six-month mortality in hospitalized patien.
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