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    Home > Active Ingredient News > Endocrine System > Get rid of fat, get rid of diabetes!

    Get rid of fat, get rid of diabetes!

    • Last Update: 2021-11-14
    • Source: Internet
    • Author: User
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    In the past ten years, with the improvement of people's living standards and changes in life>
    .

    The "five people line, there are two fat people" situation has also led to a significant increase in the prevalence of diabetes
    .

    According to the latest version of the data published by the International Diabetes Federation (IDF), as of 2019, a total of 463 million people in the world have diabetes, of which 90% to 95% have type 2 diabetes.
    On average, every 11 adults (20-79 There is 1 patient in 1 year old
    .

    By 2045, the number of diabetic patients will jump to 700 million
    .

    As we all know, diabetes is almost a disease that "Once you have it, it will accompany you for life"
    .

    For patients, medication and life>
    .

    However, for some of these patients, they became "lucky ones"
    .

    In recent years, a large number of studies have shown that patients with type 2 diabetes can be relieved or even reversed through a series of dieting methods and other life>
    .

    After all, the number of diabetic patients is too large, and there are millions of people who don't even know that they have diabetes
    .

    Earlier this year, in a new study published in The Lancet, a research team led by King’s College London, UK passed an open single-center randomized controlled clinical trial and conducted a 10-year follow-up study It is proved that metabolic surgery is more effective than traditional medicine in the treatment of severe type 2 diabetes
    .

    In this most rigorous clinical study, more than one-third of patients who underwent gastric bypass or biliary-pancreatic bypass did not have diabetes during the 10-year follow-up period
    .

    Therefore, metabolic surgery can basically "cure" type 2 diabetes
    .

    In a new study published in "PLOS Medicine" on November 3, Beijing time, a research team led by the University of Edinburgh investigated the data of almost all patients with confirmed diabetes in Scotland
    .

    They found that even in the absence of scientific intervention and metabolic surgery, almost 5% of patients successfully reversed diabetes, which is much higher than expected
    .

    In this study, the researchers assessed that the Scottish National Diabetes Registry contains data on 99.
    5% of the country’s diagnosed diabetes patients
    .

    They identified a cohort of 162,316 type 2 diabetes patients over 30 years of age based on HbA1c readings
    .

    From January 1 to December 31, 2019, a total of 7710 people entered remission due to their HbA1c readings below 48mmol/mol (6.
    5%), accounting for about 4.
    8% of the cohort
    .

    Researchers have found that individuals who are more likely to enter remission are older, have lost more weight since diagnosis, have no history of hypoglycemic therapy or bariatric surgery, and generally have healthier blood tests at the time of diagnosis
    .

    Researchers said that in routine clinical care other than trials or bariatric surgery, a considerable proportion of patients have achieved remission of type 2 diabetes
    .

    These patients should receive adequate support and follow-up to ensure that ongoing care is consistent with diabetes management guidelines
    .

    It is important to confirm that the relief of diabetes may not be permanent
    .

    The researchers emphasized that because so far, there is no international consensus on diabetes relief
    .

    Therefore, it is necessary to formulate new guidelines for people who are alleviating the disease
    .

    It is unclear whether these results in Scotland are applicable to other countries or regions, but one thing is certain: by 2045, the number of people with diabetes worldwide will increase to 700 million
    .

    We need more insights on how to reverse this disease as quickly as possible
    .

    In 2017, Professor Roy Taylor from the Institute of Translational and Clinical Research, Newcastle University, UK, put forward the "double cycle hypothesis" for the pathogenesis of diabetes for the first time through animal experiments, and believed that diabetes is a reversible disease
    .

    In order to verify his theory, he conducted a clinical trial called Diabetes Remission (DiRECT), and successfully reversed the patient's condition in the trial
    .

    In 2019, Taylor's team observed type 2 diabetes patients and confirmed that fat spilled from the liver into the pancreas, which caused diabetes
    .

    The research has been published in "Cell Metabolism"
    .

    In this two-year study, most people did not get sick again; but a small number of people gained weight and re-developed type 2 diabetes
    .

    The study found that when a person accumulates too much fat that should be stored under the skin, the fat will migrate to other parts of the body
    .

    The amount of fat that can be stored under the skin varies from person to person, but once the threshold is exceeded, it will cause harm
    .

    This study confirmed Professor Taylor's "double cycle hypothesis" that type 2 diabetes is actually caused by excess fat in the liver and pancreas, but this process is reversible
    .

    Subsequently, the team launched a large-scale DiRECT trial, which showed that weight loss can be maintained by eating a low-calorie diet, thereby achieving the effect of relieving type 2 diabetes
    .

    In the DiRECT trial, one-quarter of participants lost 15 kg or more of weight, and among these people, almost 90% will alleviate type 2 diabetes
    .

    Two years later, more than one-third of the patients had not had diabetes for at least two years and stopped all diabetes medications
    .

    Taylor said: "This means that we can treat type 2 diabetes as a simple disease, that is, the individual accumulates fat more than it can bear
    .
    The
    important thing is that through dieting and persistence, the patient can lose fat, and it may be reversed.
    Diabetes
    .
    The
    sooner it is done after diagnosis, the more likely it is that the condition will be relieved
    .

    ”Link to the paper: https://doi.
    org/10.
    1371/journal.
    pmed.
    1003828https://doi.
    org/10.
    1016/j.
    cmet.
    2019.
    11.
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