GlaxoSmithKline and IDEAYA have worked together on synthetic lethality

GlaxoSmithKline and IDEAYA Biosciences announced strategic partnerships in synthetic lethality, the emerging oncology sector, and GSK's core research priorities.In synthetic lethality, cells can cope alone with the loss of a single gene, but a combination of two or more gene defects can cause cell death. When the tumor suppressor gene loses function in cancer, this pattern of action can develop specific weaknesses for tumors through new drugs in cancer patients.The partnership includes IDEAYA's synthetic lethality program MAT2A, Pol Theta and Werner Helicase, which will conduct clinical trials over the next three years.IDEAYA has solved crystal structures for each program, facilitated structure-based drug design, and demonstrated in vivo proof of concept in relevant animal models for its MAT2A and Pol Theta programs.“ GlaxoSmithKline is the ideal strategic partner for IDEAYA because of the compelling potential combination and the opportunity to build an industry-leading synthetic lethality line for several major solid tumors, including potential lung, prostate, breast, colorectal and ovarian cancers," said Yujiro S. Hata, CEO and President of the company.Under the Partner Terms, IDEAYA will lead the MAT2A program through early clinical development and will be responsible for all costs prior to the exercise of the GSK option, after which it will bear 20% of the global research and development costs.In return, IDEAYA will receive 50% of the profit share of MAT2A and Werner Helicase's plans in the United States and royalties outside the United States, and will bear 20% of the global development costs of licensed products developed by GSK.The organization will also support the global royalties of the Pol Theta program, while GSK will bear all research, development and commercialization costs.GSK is responsible for the commercialization of all licensed products worldwide. （cyy123.com
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