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    Home > Chemicals Industry > Chemical Technology > Glycyrrhetinic acid

    Glycyrrhetinic acid

    • Last Update: 2022-06-11
    • Source: Internet
    • Author: User
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    Glycyrrhetinic acid

    Clycyrrhetinic Acid

    【Structural formula】

    [Molecular formula and molecular weight] C 30 H 46 O 4 ; 470.
    68

    [Source] The dried roots and rhizomes of the legume Glycyrrhiza uralensis Fisch
    .

    【Properties】White needle crystals
    .

    This product is easily soluble in methanol
    .

    Melting point: 282~284℃
    .

    【Purity Check】

    TLC

    1.
    Thin layer plate silica gel G

    Developing solvent petroleum ether (30~60℃)-toluene- ethyl acetate - glacial acetic acid (10:20:7:0.
    5)

    Check under UV light (365nm)

    2.
    Thin layer plate silica gel G

    Eluent petroleum ether (30 ~ 60 ℃) - chloroform - acetic acid (5 = 5: 1)

    Check 10% sulfuric acid ethanol solution, heat at 105℃ until the spots are clear, check under sunlight and ultraviolet light (365nm)
    .
    High performance liquid chromatography

    Chromatographic column HilQ-sil C 18 column, 5um (4.
    6mm×250mm)

    Mobile phase acetonitrile-0.
    02% phosphoric acid (65:35), 1ml/min

    Detection wavelength 254nm

    Differential calorimetry

    Start temperature 50℃, end temperature 300℃, heating rate 5℃/min

    【Structural identification】204,249
    .

    3440, 1720, 1700, 1620, 1460, 1380, 1210, 1150
    .

    EI-MS m/z: 470[M] + , 303, 262, 257, 216, 175, 135
    .

    1 H-NMR (CDCl 3 ) δ: 0.
    81, 0.
    84, 1.
    01, 1.
    13, 1.
    14, 1.
    22, 1.
    37 (each 3H, s, 7×CH 3 ), 5.
    71 (1H, s, H-12)
    .

    13 C-NMR (CDCl) δ: 37.
    8(Cl), 27.
    4(C-2), 78.
    9(C-3), 39.
    2(C-4), 55.
    1(C-5), 18.
    8(C-6), 32.
    9 (C-7), 43.
    3(C-8), 61.
    9(C-9), 37.
    2(C-10), 200.
    2(C-11), 128.
    7(C-12), 169.
    1(C-13), 41.
    1( C-14), 28.
    2(C-15), 23.
    4(C-16), 45.
    5(C-17), 43.
    8(C-18), 39.
    3(C-19), 48.
    4(C-20), 31.
    1(C -21), 31.
    9(C-22), 28.
    6(C-23), 16.
    4(C-24), 15.
    6(C-25), 17.
    6(C-26), 26.
    6(C-27), 26.
    6(C- 28), 28.
    4 (C-29), 180.
    4 (C-30)
    .

    【Storage】Dry and airtight
    .

    Related link: Naringin

     

     

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