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    Home > Active Ingredient News > Study of Nervous System > GnRH replacement therapy has had amazing benefits for people with Down syndrome

    GnRH replacement therapy has had amazing benefits for people with Down syndrome

    • Last Update: 2023-01-06
    • Source: Internet
    • Author: User
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    This article is from NEJM Journal Watch

    Surprising Benefit from GnRH Replacement in Down Syndrome

    Amazing benefits of GnRH replacement therapy for people with Down syndrome

    Reviewed by Anthony L.
    Komaroff, MD

    Pulsed gonadotropin-releasing hormone for 6 months in patients with Down syndrome (DS) improves cognitive function

    Trisomy 21, or DS, causes progressive cognitive impairment at a young age, as well as premature deposition
    of Alzheimer's disease-like brain plaques and tangles.
    European researchers have observed that DS patients also have fewer neurons producing gonadotropin-releasing hormone (GnRH) over time, so they wanted to understand whether this was the cause
    of cognitive loss.

    Using a trisomy 21 mouse model (such as DS patients, which also have low fertility, progressive cognitive decline, and fewer neurons that produce GnRH), the researchers found that GnRH neuronal reduction was associated with altered expression of several microRNAs (miRNAs), including a reduction
    in miRNAs known to promote the maturation of GnRH neurons.
    Supplementation of this miRNA increases the number of GnRH neurons
    This intervention, or pulse, was given to GnRH itself, which improved cognitive function
    in these mice.

    Seven patients with DS (mean age, 26 years; These patients were determined by functional magnetic resonance imaging to have cognitive impairment and brain network connection impairment) received pulsed GnRH therapy for 6 months: 6 patients had improved cognitive function and brain network connectivity


    The results of this small human study are shocking, and the mouse study suggests that the mechanism seems plausible
    Progressive loss of GnRH neurons may be one of
    the causes of cognitive loss in DS patients.
    There seems to be a need for larger controlled trials
    of DS and possibly Alzheimer's disease.

    Articles that were commented on

    Manfredi-Lozano M et al.
    GnRH replacement rescues cognition in Down syndrome.
    Science 2022 Sep 2; 377:1064.

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