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    Home > Food News > Nutrition News > Good Cholesterol Helps Treat Sepsis

    Good Cholesterol Helps Treat Sepsis

    • Last Update: 2022-04-24
    • Source: Internet
    • Author: User
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    Supplementing the body's high-density lipoprotein (HDL) may be an effective treatment for sepsis, according to a new study published in Science Signaling at the University of Kentucky School of Medicine


    Laboratory research led by Dr.


    Sepsis is a life-threatening disease that occurs when an infection sets off a chain reaction throughout the body


    HDL cholesterol is called "good" cholesterol because it helps remove other forms of cholesterol from the blood


    In collaboration with co-investigators at the University of Michigan Hospital's Intensive Care Unit, the study showed that septic patients had lower levels of HDL cholesterol compared to non-septic patients


    According to this study, combined with Li's previous studies in HDL-deficient mice, these findings suggest that reduced HDL abundance is a risk factor for sepsis, and that increasing HDL abundance may provide a viable strategy for treating sepsis


    To test this hypothesis, Li's team treated mice with sepsis with a synthetic HDL called ETC-642.


    "Overall, these data suggest that HDL therapy may be an effective treatment for sepsis," Li said


    ETC-642 was previously developed for the treatment of cardiovascular disease and has been shown to be effective in raising HDL levels in patients in several clinical trials



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