Good medicine master Wang Zhenyi: for the world's patients to seek

the prize not given to young people? Mr
Zhenyi, 96, recently won the 2020 Future Science Award, a million-dollar prize.
"Can you return this award?" Can't you? Then donate all the prize money. "
people who know each other quietly told reporters that this is not the first time the old gentleman donated the prize money.
science and technology awards are a reward for scientific researchers, but for the old man, he is more concerned with the training of young scientific research personnel. He is also concerned about the family's flowers and grasses to water on time, guests visit to hurry out of chocolate a piece of good ... In his eyes, everyone is a child. If someone likes to enjoy the symphonies on the computer with him, he will be happier.
"Oh, I'm 'old oil bar', live a long time, we may be bored. "When 96-year-old Wang Zhenyi finished, he was happy.
not play cards according to the way, this may be Wang Zhenyi's character in a very distinctive side. From the doctor 78 years, in Wang Zhenyi's own words: if "too obedient", has been walking the old road, safe, do not fall, but also can not find the fruit of the new road.
The old man said that the clouds light, open his generation, can read this experience after grinding the weight as light -
Wang Zhenyi is a well-known hematologist in China, the country's highest science and technology award winner, the Chinese Academy of Engineering
, Shanghai Jiaobi University School of Medicine affiliated with Ruijin Hospital tenured professor. He has a lot of medical theory and practice innovation, the most relished is he and students Chen Wei, Chen Saiyi, Chen Guoqiang and others established acute early granulocytic leukemia (APL) "Shanghai program", making APL the first curable tumor in the history of human tumor therapy. Wang Zhenyi was thus praised as "the first person in the history of human cancer treatment to succeed in the application of induced differentiation therapy".
Zhenyi is a generation of famous doctors, but also a generation of mentors. Before this year's Teacher's Day, the reporter came to Wang Zhenyi's home to listen to the old gentleman talk about medical life, talk about the road to scientific research and discovery, talk about patients and cases, talk about youth post-school training.The "Life Sciences Award" of the 2020 Future Science Award was awarded to Wang Zhenyi
, a tenured professor at Ruijin Hospital, in recognition of his decisive contribution to the APL, with Professor Zhang Tingdong of Harbin Medical University's First Affiliated Hospital as the co-winner.
faced with the question of "how to allocate the bonus", 96-year-old Wang Zhenyi said: "Trouble hospital to help me all donate to the poverty relief foundation."
, Mr. Wang, received the phone call at a time agreed by the grand prize organizers, and when asked about his winning mood, he said frankly that he was in a good mood and had a "bad" mood. "On the one hand, our country values science, and research is praised and rewarded for its benefit to the people, and of course it's great to be a winner, as if the pie had been dropped in the sky." But on the other hand, I'm worried, why isn't this award going to young people? To this day, every day there are still patients with acute leukemia died, I am very sad, feel that we have worked for decades to solve only one type of leukemia, not all acute leukemia. Rewarding young people encourages them to continue their efforts to move forward and realize our ideals on the path we have opened up. "
at home, with reporters again talk about this award, the old man said the most or young scientific research personnel training. In his memory, Britain had a scientific institution that had five Nobel laureates. Why is it so "high-yielding"? Because they have been studying around an important scientific topic, generation after generation.
"Science is not exhausted, you solve a problem, the second problem comes out, so this institution will be born five Nobel Laureates." Wang Zhenyi lamented that the atmosphere of scientific research is particularly important for the growth of young people.despite retiring from management positions for more than 20 years, Wang Zhenyi is still concerned about the development of disciplines and will listen to young people make scientific research reports. One year, he heard a good scientific research results, said that the discovery of a possible leukemia-related gene, but he particularly regretted that the next year to listen to the young man report, scientific research has become another direction.
you're constantly changing your research direction, and the difference between each research direction is so great, how can you make a breakthrough finding?" he said. How can we get an important research result that is really relevant to solving the major diseases of ordinary people? "The old gentleman later found out that it was not the young man who was "not qualitative." Our current evaluation criteria are often still looking at papers, not much emphasis on practical ability to work. The consequence of this is that young people see where to send papers fast, put in which direction, do this this year, next year will turn the gun to do that. "When it comes to this, the old gentleman is very anxious, because in his opinion, to judge a young medical research work, depends on whether there is innovation, research. Because success is not a matter of day or two, medical research and even the road of discovery, is often a lonely road - from clinical discovery of problems, to basic research breakthroughs, to the successful application of clinical treatment of patients, this is an incredibly long road, few passers-by.
of course, the evolution of modern medicine lies in the countless faith-based doctors who go to follow and even seek life, and finally pick up a little new discoveries on the path of science.
Wang Zhenyi will have this feeling, because he himself came here.Wang Zhenyi was born in 1924 in a "well-off house" in Shanghai, and at the age of seven, Wang Zhenyi's favorite grandmother died of typhoid fever. Why can't the disease be cured? How did you get this disease? Is there really no way? From an young time like to ask "why" he, in this heart buried the seeds of medical study.
1942, Wang Zhenyi entered Zhendan University (the predecessor of Shanghai Ishi University Medical College) and decided to study medicine. In 1948, Wang Zhenyi graduated from Zhendan University Medical College with a doctorate in medicine, and stayed at Guangci Hospital (the predecessor of Ruijin Hospital) as a resident.
in 1952, the hospital department was adjusted, and the general medical department tended to specialize. At that time, Wang Zhenyi thought that "blood disease is simpler, that is, take a microscope to see how the cells, you can diagnose", so choose to specialize in the direction of blood disease in internal health. What he didn't expect was that this seemingly "simple" disease was not simple, but the most complicated, making him seek a lifetime.
, everyone said that Wang Zhenyi is the first person to induce cancer cells to "change their innocence", the starting point of the story has to start from leukemia treatment.
the 1970s, Wang Zhenyi officially and leukemia "tricks." Acute early childhood leukemia was once one of the most dangerous in the leukemia family, and many patients often die within hours of being rescued. Until the 1980s, there was no effective treatment for it worldwide, and doctors around the world were frustrated.
the 1970s, Wang Zhenyi began an expedition into the unknown. "At that time, there was still a shortage of supplies, and the simplest cell culture we would not have had to go out to study." Wang Zhenyi recalled that at that time, the research is very difficult, some people go abroad to meet, bring some information back, in such limited conditions, they heard about "induced differentiation." However, no one knows what to do to "induce differentiation" of tumor cells into good cells.
at that time, the Ruijin Hospital blew the wind of scientific research, hematology research from a small laboratory started. Through "hearseeing", Wang Zhenyi learned that an amino acid may make the tumor "correct, induce differentiation". He took the students to find a way to synthesize the amino acid, with great hope. The first graduate student he taught did is this topic, as a result, graduate students graduated, the paper was published, the specific method used in patients but no effect.
exploration into a "dead end", time and time again frustrated against the doctor's blow is difficult to describe in words. "This road is probably not going to work..." In the same research direction, many laboratories around the world have accepted the status quo, but Wang Zhenyi's team did not.
, they learned that the U.S. had induced the differentiation of tumor cells with a drug called 13-shunviric acid, which is used to treat APL and yield results that were effective for individual patients, the results of which were published in the international journal Blood.
Zhenyi recalled that there was no 13-shun-vinyl acid in China at that time, but there was an all-reverse form of methiciltic acid, which was approved at the time for the treatment of skin diseases. So, we are excited to find the drug factory, pharmaceutical engineers heard that the doctor to use drugs to study how to save lives, sent a few boxes of medicine to this group of doctors. in-body research began. Wang Zhenyi led the graduate students through a series of experiments, found that vitamin A oxide - all-trans methiciltic acid can be in vitro experiments in the infant leukemia cells into mature cells. The doctors were overjoyed. However, there are some side effects of all-trans methicillin, and the clinical application of new therapies that have never been reported internationally is under great pressure.
in 1986, they waited for the "001" patient. The hematology department of Shanghai Children's Hospital treated a 5-year-old patient in a critical condition. This is the hospital where Wang Zhenyi's wife, children's hematologist Xie Jingxiong, works.
see the little life dying, Xie Jingxiong is very anxious. "I'm working on this, you try it." Wang Zhenyi proposed. In the face of this unprecedented treatment, the child's parents agreed to a fight, "dead horse as a living horse doctor"!
a course of treatment, the condition really eased! The small patient was eventually cured, survived and has been married and had children. This is the first successful case of inducing differentiation theory to "correct" cancer cells. In 1988, Wang Zhenyi's related results were published in Blood, which was a sensation in the medical field. In 2000, the paper was listed as one of the "86 papers with the highest and most influential citation rate in the world in a hundred years".
After, Wang Zhenyi and students Chen Wei, Chen Saiyi, Chen Guoqiang and other creative "all-trans-remeric acid combined arsenic trioxide" treatment method, so that this was once regarded as the most dangerous leukemia acute early granulocytic leukemia, becoming the world's first curable leukemia. The treatment was hailed
as the "Shanghai Program" and listed as "the eight great contributions of new China to world medicine in the 20th century" in combination with the invention of artemisinin.
Wang Zhenyi won the Kettering Prize, the highest award in the international oncology community. The Kettering Prize has never been awarded to Chinese before, and the jury called Wang Zhenyi "the first person in the history of human cancer treatment to succeed with induced differentiation therapy."
this study after at least three generations of the Shanghai Institute of Hematology relay, stretching for half a century of research is still going on ... Now readers seem to feel comfortable looking back on this "concentration discovery history", unbeknowed by the eight-year silence of the study, which turned 62 years old when the "001" patient turned around in 1986.
, there are also a lot of people kindly persuaded: you are more than 60 years old, don't toss, carefully ruined the name. And Wang Zhenyi said a word at that time: "I for the sake of patients, I have a test basis, I believe in science." After decades as a doctor, Wang Zhenyi helped patients come back from the dead. In his heart, loaded with the great love of the world of Shendian. This love, to the young, to this profession, but also to all the patients of the world.
In the past eight months or so, the world has experienced the worst pandemic of infectious diseases in a hundred years, witnessing the feelings of doctors and patients who live and die in times of crisis, Wang Zhenyi feels the same way, but also has a new way of thinking. Citing the "inflammatory storm" caused by the new coronavirus as an example, he likened doctors to "centrists" who "have too strong an immune response and a great risk, but they can't go unresponsive." A good doctor is going to be an 'old lady uncle' and tell 'everybody don't make a fuss'. In the end, the medical problem became a philosophical problem, paying attention to the middle way, and the immune function was balanced".
Wang Zhenyi is also physically strong, during the anti-epidemic period continued to sow love for patients. On May 15th this year, at the age of 96, he continued the "open-book examination" he had been holding for more than a decade. In 2003, after he "let hyun" all his administrative posts, he created this special way of checking the room, that is, every Monday by students to submit clinically difficult cases, forming a "test paper", he searched the world's latest literature within a week, thinking, analysis, "answer", and every Thursday with you to discuss.
"We must not be too demanding of scientific research results, scientific research must take time. And I am an 'old oil bar', old, there is no work to carry out another 5 to 10 years to produce results of research, I can now learn to sell some work, 'open book examination' is one of them. Wang Zhenyi said.
that day, with the help of a "Snowy" robot equipped with 5G technology, remote stethoscope, and synchronous HIS (electronic medical records) images, Wang Zhenyi and a 74-year-old patient connected in the "cloud" to begin his "answer time".
The patient's blood clotting function is abnormal, 10 days before hospitalization, lumbar acid, lower limb fatigue, no fever, but there is a special phenomenon: the left leg appears a large area of bruises, suggesting bleeding in the body. The treatment team initially considered that fibrinogen was reduced, causing bleeding, but tests found that this did not make sense. Then consider whether it is amyloid change, detection found that the patient's m protein is negative, so do not first consider amyloid change ... This "trap-heavy case" allows the team to repeatedly suffer "hypothetical, overturned, then hypothetical, and then overturned" blows.
time is life, in the face of many "traps", Wang Zhenyi from the "asymptomatic autoantibodies" "fibrin dissolving function into" "guarine fibrinogenemia" three pathophysiological perspectives, will be a lot of clinical phenomena explained.
"They gave me the hardest 'topic'." Wang Zhenyi gave his "open-book exam" an average score of 90 points, "some 'questions' can get to 95 points, because the patient's problem is basically solved." I ask doctors must do follow-up, diagnosis is correct or not, the most critical criterion is the patient's treatment effect, can not be blown casually." to solve the problem, this is Wang Zhenyi's life unremitting exploration of the source of medical innovation, but also his constant doctor's first heart, and solve the problem is not to solve their own problems, in the final analysis, is to solve the world's patients' problems! on the day of the
interview, Wang Zhenyi just completed a new round of "open-book examination" answer, he happily invited reporters into his study, in front of the computer to show his problem-breaking process, a 52-page Chinese and English PPT, which he achieved in less than 24 hours.
monday morning, he got it