Grapefruit and fat-lowering medicine to eat "muscle dissolution"? Expert: Take grapefruit with caution during medication

Original title: Grapefruit and fat-lowering medicine to eat "muscle dissolution"? Experts: Take grapefruit carefully during the drug
and to a large number of grapefruit market season, because of its rich nutrition, fire cough and other effects by many people's favorite. However, eat grapefruit should also be careful, Wuhan 58-year-old Mr. Liu took the fat-lowering drug Atovastatin took some grapefruit, resulting in "transverse muscle dissolution syndrome."
" transverse muscle dissolution refers to transverse muscle cell damage caused by physical, chemical, biological or pharmaceutical factors, some substances in the cell, including myoglobin, creatinase, etc. are released into the blood caused by environmental disorders. "Jin Rui, deputy director of Beijing Century Temple Hospital, said that the main symptoms of transverse muscle dissolution syndrome are muscle weakness, muscle soreness, etc., after examination will find creakinase elevation, serious cases may even be accompanied by renal failure." The combination of grapefruit and atovastatin increases the probability of transverse muscle dissolution.
Thratin in grapefruit will inhibit some drug metabolism
Jin Rui introduced, grapefruit contains "Bergin", this ingredient will inhibit CYP3A4 metabolase, and atovastatin is metabolized by CYP3A4 metabolic enzyme, if the drug is taken at the same time intake of grapefruit, meaning that the drug can not be metabolized in the body, can only accumulate in the body, equivalent to the human body overdosed on drugs, the possibility of side effects will be greatly increased.
in theory, in addition to atovastatin, other drugs that need to be metabolized by CYP3A4 metabolic enzymes are affected by grapefruit, such as statins, simvastatin, lovastatin, etc.; Jin Rui added.
avoid eating grapefruit, grapefruit juice
" grapefruit (grapefruit) and regular grapefruit when taking the drug, but the variety is different. Jin Rui said that some scholars from all over the country to find 39 grapefruit, to determine the content of bergamot. Overall, most grapefruits do not have high levels of bergamot. Citrus fruit graft varieties are numerous, and if it is mixed with grapefruit during grafting, the fruit may contain bergamot. "Scientific studies have only clearly confirmed that grapefruit contains high levels of bergamotin, and there is a lack of research on other citrus fruits."
recommends avoiding large amounts of grapefruit juice or grapefruit when taking the drug for safety reasons, in order to avoid elevated blood concentrations or side effects of the drug in the body.
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