echemi logo
Product
  • Product
  • Supplier
  • Inquiry
    Home > Active Ingredient News > Endocrine System > Graves new markers of eye disease! Studies have found that cholesterol levels are closely related to GO 2022 ATA

    Graves new markers of eye disease! Studies have found that cholesterol levels are closely related to GO 2022 ATA

    • Last Update: 2022-10-20
    • Source: Internet
    • Author: User
    Search more information of high quality chemicals, good prices and reliable suppliers, visit www.echemi.com
    Yimaitong compiles and organizes, please do not reprint
    without authorization.

    Introduction: A study from Campinas State University in Brazil found that high levels of low-density lipoprotein cholesterol (LDL-c) often mean more severe Graves eye disease (GO), LDL-c or a new marker for GO
    .
    The findings were presented
    at the 2022 American Thyroid Association Annual Meeting (ATA).



    What factors may influence the development of GO?

     

    Graves' orbitopathy (GO) is the most common outward manifestation of
    thyroid disease.
    Poorly controlled hyperthyroidism, smoking, male sex, age, and genetic factors are all risk factors
    for GO.
    Studies have shown an association between GO and high levels of total cholesterol and LDL cholesterol, and the mechanism remains to be understood
    .
    This study aimed to assess the relationship between cholesterol levels and GO, including disease activity and severity
    .

     

    This retrospective study included 166 patients with Graves disease treated with methimazole and assessed GO status using clinical activity scores, NOSPECS, and EUGOGO evaluation criteria
    .
    Group 1 was non-GO or mild GO patients (CAS and NOSPECS score 0~2, EUGOGO evaluation was mild), and group 2 was active GO patients (CAS and NOSPECS score ≥3, EUGOGO evaluation was moderate, severe, and sight-threatening).

    The following variables were included for analysis: sex, smoking, thyroid antibodies, TSH, free T4, physical activity, total cholesterol levels and related indicators
    .

     

    New GO markers: High levels of LDL-c often mean more severe GO

     

    The LDL-c (p<0.
    0037) and total cholesterol (p<0.
    0088) levels were significantly higher and their age was significantly greater (p<0.
    0029) in the two groups according to the CAS score, and there were no significant differences
    in other variables.
    LDL cholesterol (p<0.
    005) and total cholesterol (p<0.
    0221) were higher in EUGOGO-rated group 2, with no significant differences
    between other variable groups.
    In NOSPECS-rated group 2, LDL cholesterol (p<0.
    0002) and total cholesterol (p<0.
    001) were higher and older (p<0.
    03), with no significant differences
    between groups in other analytical variables.

     

    Univariate logistic regression analysis showed that LDL cholesterol and total cholesterol were significantly associated with more severe GO (p=0.
    007, p<0.
    01).

    According to multiple regression analysis, high levels of LDL-c were associated with more severe GO (p<0.
    05).

     

    Summary of this article

     

    This study found that high levels of LDL cholesterol may be a new marker of
    Graves' eye disease.
    Does treatment reduce the risk of GO and improve outcomes? Further exploration
    is needed in the future.

     

    REFERENCE: THE IMPACT OF CHOLESTEROL LEVELS ON GRAVES' ORBITOPATHY.
    THYROID Volume 32,Supplement 1,2022.
    https://doi.
    org/10.
    1089/thy.
    2022.
    29140.
    lb.
    abstracts

    This article is an English version of an article which is originally in the Chinese language on echemi.com and is provided for information purposes only. This website makes no representation or warranty of any kind, either expressed or implied, as to the accuracy, completeness ownership or reliability of the article or any translations thereof. If you have any concerns or complaints relating to the article, please send an email, providing a detailed description of the concern or complaint, to service@echemi.com. A staff member will contact you within 5 working days. Once verified, infringing content will be removed immediately.

    Contact Us

    The source of this page with content of products and services is from Internet, which doesn't represent ECHEMI's opinion. If you have any queries, please write to service@echemi.com. It will be replied within 5 days.

    Moreover, if you find any instances of plagiarism from the page, please send email to service@echemi.com with relevant evidence.