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Introduction: A study from Campinas State University in Brazil found that high levels of low-density lipoprotein cholesterol (LDL-c) often mean more severe Graves eye disease (GO), LDL-c or a new marker for GO
.
The findings were presented
at the 2022 American Thyroid Association Annual Meeting (ATA).
What factors may influence the development of GO?
Graves' orbitopathy (GO) is the most common outward manifestation of
thyroid disease.
Poorly controlled hyperthyroidism, smoking, male sex, age, and genetic factors are all risk factors
for GO.
Studies have shown an association between GO and high levels of total cholesterol and LDL cholesterol, and the mechanism remains to be understood
.
This study aimed to assess the relationship between cholesterol levels and GO, including disease activity and severity
.
This retrospective study included 166 patients with Graves disease treated with methimazole and assessed GO status using clinical activity scores, NOSPECS, and EUGOGO evaluation criteria
.
Group 1 was non-GO or mild GO patients (CAS and NOSPECS score 0~2, EUGOGO evaluation was mild), and group 2 was active GO patients (CAS and NOSPECS score ≥3, EUGOGO evaluation was moderate, severe, and sight-threatening).
The following variables were included for analysis: sex, smoking, thyroid antibodies, TSH, free T4, physical activity, total cholesterol levels and related indicators
.
New GO markers: High levels of LDL-c often mean more severe GO
The LDL-c (p<0.
0037) and total cholesterol (p<0.
0088) levels were significantly higher and their age was significantly greater (p<0.
0029) in the two groups according to the CAS score, and there were no significant differences
in other variables.
LDL cholesterol (p<0.
005) and total cholesterol (p<0.
0221) were higher in EUGOGO-rated group 2, with no significant differences
between other variable groups.
In NOSPECS-rated group 2, LDL cholesterol (p<0.
0002) and total cholesterol (p<0.
001) were higher and older (p<0.
03), with no significant differences
between groups in other analytical variables.
Univariate logistic regression analysis showed that LDL cholesterol and total cholesterol were significantly associated with more severe GO (p=0.
007, p<0.
01).
According to multiple regression analysis, high levels of LDL-c were associated with more severe GO (p<0.
05).
Summary of this article
This study found that high levels of LDL cholesterol may be a new marker of
Graves' eye disease.
Does treatment reduce the risk of GO and improve outcomes? Further exploration
is needed in the future.
REFERENCE: THE IMPACT OF CHOLESTEROL LEVELS ON GRAVES' ORBITOPATHY.
THYROID Volume 32,Supplement 1,2022.
https://doi.
org/10.
1089/thy.
2022.
29140.
lb.
abstracts