"Gun" war virus . . Key Lab Parade

(1) Gao Fu (1) instructs students to do experiments(2) Yan Jinghua in the observation of bacterial fall status(3) Shi I (right 2) to guide students to do experiments(4) Researchers in observation cells(5) researchers in mammalian cell experiments(6) "micro" sculpture, this sculpture is an open articulated treatment of influenza virus In order to commemorate the contribution of the scientific research team with the Chinese Academy of Sciences as its core, in the fight against influenza (7) Microbiology Institute and Yabao Pharmaceuticals signed a cooperation agreement on "anti
-new coronavirus antibody technology Relying on the establishment of the Chinese Academy of Sciences pathogenic microbiology and immunology key laboratory (hereinafter referred to as the pathogen chamber) is a major battleground for Gao Fu to do scientific research. He has been the director of the laboratory for more than ten years.
The embers of the new crown pneumonia epidemic in China are still there, as the director of the China Center for Disease Control and Prevention, Gao Fu's daily schedule is overloaded, he can only give the task force a meeting in the evening, and we communicate new progress, planning the direction of research.
months, the pathogen room war "epidemic" has been frequently reported. And that's all thanks to years of precipitation.
more than ten years of development, the pathogen chamber in the virus cross-species mechanism transmission research has been in the forefront of the international. However, Gao Fu is still always "knocking" and "whipping" the researchers in the room: "Must keep a clear head, if you do not work hard will fall out of the team, become the rabbit in the race of the tortoise and rabbit." In , a sudden outbreak of new crown pneumonia cast a huge shadow over the Spring Festival of the Year of the Rat, and the changes in the outbreak touched the hearts of the public. As a member of the scientific and technological "national team", microorganisms so the pathogen chamber as the core, from the new coronavirus traceability, transmission mechanism research to rapid detection of technical testing, to antibody and vaccine development, virus database construction, etc. , quickly multi-directional, full-chain layout.
the face of the outbreak, every researcher at the Microbiology Institute tightened the heart's hair. They made the lab their home, working around the clock and overtime. "Everybody's desperate." Looking back over four months, says Qian Wei, director of the Institute of Microbiology.
the outbreak, Yan Jinghua and Gao Fu team undersprotegen vaccine, one of the five routes of the Ministry of Science and Technology vaccine, as well as the new coronary pneumonia antibody drug research. In the face of public thirst for drugs and vaccines, the two projects have put enormous pressure on researchers. In order to produce results quickly, researcher Wang Qihui was even tired of high-frequency deafness.
after months of "sprinting", Yan Jinghua, Gao Fu, Wang Qihui team of cooperation is not expected, and constantly out of the good news. On June 5, a clinical trial of the new coronavirus all-human monoclonal antibody jointly developed by the Institute of Microbiology and Junshi Bio was approved by the State Drug Administration, the first clinical trial of a new coronary pneumonia therapeutic antibody in a healthy population after the completion of the non-human primate experiment. At the same time, Gaofu and the Capital Medical University,
Beijing Institute of Life Sciences and other institutions in cooperation with researchers isolated another group of human-origin antibodies, has also entered the preclinical trial stage.
June 19, a new coronary recombination protein vaccine developed by microorganisms was approved for Phase I clinical trials. Different from the adenovirus vector vaccine and inactivated vaccine previously approved for clinical trials, this is a new coronavirus vaccine developed along the new technology route, which features the production of the most effective antigen component gene of a pathogen for in-body recombination and then vaccine. Recently, the Institute of Microbiology's second vaccine, the recombined chimpanzee adenovirus vector new crown vaccine, has also reached an agreement with enterprises to develop, is currently in the pre-clinical preparation stage.
, two groups of human-origin antibodies and two vaccines from the Microbiome Institute are moving forward.
not only that, the above-mentioned research results have been published in Nature, Cell, Science and other journals, in which antibody research and transformation output of more than 200 million yuan, from basic research to economic benefits. "The combination of production, learning and research is very important, in order to do a good job of transformation, from the beginning to run to the product." Yan Jinghua told China Science Daily that at the beginning of the vaccine and antibody research and development, the task force used the previously established cooperative relationship to invite enterprises to participate. "Otherwise, what the lab does can't be quickly translated into a product."
At the same time, other achievements in the pathogen chamber were reported: Shi's team revealed the near-atomic resolution structure of the core polymerase complex of the new coronavirus; Qi Jianxun's team analyzed the crystal structure of the new coronavirus RBD and the human ACE2 complex; and Bi Yuhai's team pioneered the development of the new coronavirus nucleic acid. Testing kits, donated more than 20,000 copies across the country, as a vaccine must constitute antigens, adjuncts, one of the two major elements, Meng Songdong team developed the only natural adjunct for clinical use - gp96-mediated T-cell ad adhesive has reached the level of clinical production, become a technical reserve for vaccine research and development.
In addition, the world's first "nylon 56" material, synthesized by the Wentingyi team, went into production in Heilongjiang at the end of August, producing enough to produce millions of protective suits per day, making up for the often missing "protection" research in biosecurity prevention and control. It should be pointed out that the material broke the long-standing U.S. "nylon 66" technology monopoly, not only has flame retardant, but also has moisture absorption, easy dyeing and low raw material prices, is the production of military uniforms, medical protective clothing and other ideal materials. Wen Tingyi introduced that the original technology from corn to clothing materials has recently been transformed, the transfer fee of 120 million yuan.
" to do research must be a combination of peace, 'flat' when doing things to be able to solve the 'war' needs. Gao Fu stressed.
with the outbreak of the short soldiers, the pathogen room handed over a shendian "report card." And supporting this microorganism anti-epidemic chain linkage, is the laboratory more than ten years of innovation and precipitation. scientists are not real scientists if they don't solve the scientific problems that China's social development needs are targeting. Gao Fu said, "Scientific issues must be effectively connected with social problems, research results either go to the shelves, into textbooks, or on the shelves, into products, to solve the actual needs." In
, this is also the mission and meaning of the pathogen chamber.
the history of the disease chamber dates back to the virological laboratory established in 1958 when microorganisms were established, when research was dominated by plant viruses. In the 1990s, in the context of human health and social security,
academician Tian Bo led the establishment of an open laboratory for molecular virology and bioengineering, moving towards animal virology. In 2004, the return of Gao Fu and Liu Wenjun allowed the power of this direction to begin to grow.
"Initially there were only 'two or three guns', no tall instruments, no good articles." As soon as someone comes to apply, they'll do it right away. Liu Wenjun, deputy director of the Pathogen Room, is still in sight when he talks about creating a laboratory together at the beginning of his return. In the key subject positioning, taking into account the lack of research field of pathogenic microorganisms in China after SARS, the two men set the main direction in the field of pathogenic microorganisms and immunity, set up a molecular virus center and molecular immunity center.
in 2005, Gao Fu et al.'s research on the infection of waterfowl infected with avian influenza H5N1 in Qinghai Lake was published in Science, which is the first study in the world to describe the large number of deaths of waterfowl populations infected with avian influenza virus, which has received international attention. At the same time, Liu Wenjun's research on animal interferons also began to produce results and obtain application patents. These achievements lay the foundation for the development of the post-pathogenic chamber discipline.
2008, in the context of microbiological disciplines, the Open Laboratory of Molecular Virology and Bioengineering merged with the Molecular Virus Center and the Molecular Immune Center, and the pathogen chamber was born and upgraded to a
-key laboratory. Pathogen chambers are also gradually developing pathogenic organisms and microbiomes, immunobiology and tumor immunity, as well as drugs, vaccines and cell therapy three major research directions.
"All research directions are to solve the problem of 'card neck' plus 'card brain', which restricts China's economic and social development." Mr Goforth said the questions answered in three directions were innately relevant. Why do viruses such as avian influenza and new crowns spread across species? How is the body immune to the interoperability of viruses and hosts? What drugs, vaccines, and therapies are available to fight the virus? To answer these questions, the first two directions are more inclined to basic research, while the third direction is more applied research.
, Qian Wei said, the biggest development advantage of the pathogen chamber is the resonance with the country, a good combination of the country's major strategic needs. Since 2008, all the research on new outbreaks of infectious diseases at home and abroad, can see the presence of the pathogen chamber - avian influenza, swine flu, Middle East respiratory syndrome, Ebola virus, Zika virus, a field of scientific research and research on the disease chamber on the outbreak of the ability to respond to the outbreak.
the new coronary pneumonia epidemic, the rapid advance of the whole pathogen chamber research, but also because of these accumulations.
Today's pathogen chamber has developed from the original "two or three guns" to "more than ten guns", with 19 research teams and P3 laboratories and other advanced support platforms, in the new outbreak of infectious diseases, hepatitis, tuberculosis, tumors and autoimmune diseases research has made an important breakthrough, the realization of "cells" "nature" "Science" "The Lancet" "New England Journal of Medicine" and other international top articles of the "Grand Slam", at the same time, industrial transfer of economic income reached 500 million yuan.
recent years, laboratories have paid more attention to the transformation of results transfer. Such as Liu Wenjun task force's animal interferon patent has been transferred more than 10 million yuan, these interferons or can treat animal infectious diseases, or alternative antibiotics to achieve green farming, has achieved international recognition; The Wentingyi Task Force relies on microbiology institutes to establish research institutes with governments or enterprises in Ningxia, Nanjing, Zhejiang and other places to promote the flowering of high value-added achievements such as bio-based diamine and nylon 56, L-alanine (widely used in the food, health and pharmaceutical industries), N-laurel L-alanine
(a new generation of green decontamination synthetic compounds) and so on. Microbiology, high-tech, large industry", the pathogen chamber with a real results to explain the vision of microorganisms.
" a good laboratory to have to go in and out, learn to make their own blood, can not rely on the state's financial allocation alone. Wenting said. Relying on microbiology institutes and pathogen chambers, Wen Tingyi and Ningxia, Nanjing, Zhejiang and other places of government or enterprise jointly established research institutes are promoting a number of results out of the laboratory, into public life.
Zhu Baoli, a researcher who has been studying pathogenic microorganisms and human gut microbiomes, agrees. "If we can join forces with businesses and do this piece of industry, we can subsidize young people a little bit, otherwise good people won't sign up." He confessed. more than ten years of leapfrogging development, the study of pathogen chambers has entered the international first square, especially in the field of new outbreaks of infectious diseases, attracting many world-class scientists to cooperate. For this young lab, however, it's only just beginning - there's no end to the "first-class" in the heart of the pathogenic chamber.
have high hopes for this
laboratory, the Institute of Microbiology and Microbiology. During the 13th Five-Year Plan period, the pathogen chamber, as the main body, under assumed the
Strategic Pilot Special (Class B) "Pathogen Host Adaptation and Immune Intervention", and devoted itself to achieving breakthrough results in the areas of influenza universal vaccine, immunotherapy for infection and infection-induced tumors, and early warning and prediction of new re-emerging infectious diseases. At the same time, the pathogen chamber also played an important role in the complete innovation value chain built around "life and health" by microorganisms from source innovation, core technology to industrial transformation.
" in the context of the establishment of the Biosecurity Science Center, for some time to come, microbiology will take great safety, health as the strategic direction, towards the development of the country's major strategic needs to work towards. Chanway said. The study of the pathogen chamber will provide important support for achieving this goal.
the pathogen chamber tomorrow? In Qian Wei's view, the key lies in people. In the selection of young talent, microorganisms are not rigid, whether it is the local training of talent, or returning talent, "heroes do not ask the place of", all to virtue and ability as the first. In order to train the backbone of young scientific research, the Institute has also launched a "Youth Research Group Leader" featured program, once supported, young people in the associate researcher period can be "independent", and access to independent laboratories, start-up funds, postgraduate indicators and other resources tilted.
through this environment, we want him to go from being a soldier to a general here," he said. Chanway added.
"post-85" researcher Shi I is a microbial institute and pathogen chamber culture such a "general." He was hired as a researcher at the age of 30 for his work in pathogen research, setting a record for the youngest researcher in the institute and even
at the time. In 2018, Shi I served as deputy director of the pathogen room, and in 2019 he has served as a member of the Party Committee and the Committee of the Institute of Microbiology, which are microbials through the "burden" to train young people.
" laboratory has formed a better talent ladder, the current proportion of young people under 45 years of age more than 77%, the average age of 39 years old. "A introduction. These include 2 winners of the National Fund for Distinguished Youth and 4 recipients of the National Fund for Outstanding Youth.
" scientific research is free growth, independent exploration. After returning from Harvard in the United States, Liu Cuihua has done research at the Foundation Institute of the Chinese Academy of Medical Sciences, the 309th Hospital of the People's Liberation Army and other institutions, and in 2010 she was introduced to the Institute of Microbiology as a young research team leader, gaining the opportunity for independence. She said so.
for leading the research team in tuberculosis research outstanding achievements, in 2018, Liu Cuihua was awarded the National Science Fund for Outstanding Young People of the year project funding, and was selected as the national 10,000 people program scientific and technological innovation leader. She was also appointed Deputy Director of the Pathogen Room in 2019. In her view,
is the best "brand institution" to do research. "Research is heritageal, and the impact on the process can be beneficial for life."
and different, across innovation. This is the room training of the pathogen chamber. "And different, is to hope that each research group has its own independent academic direction, but also can be integrated into the large regiment combat;