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    Home > Active Ingredient News > Infection > Gut: Abnormal liver function at admission is related to the severe course of SARS-CoV-2 infection

    Gut: Abnormal liver function at admission is related to the severe course of SARS-CoV-2 infection

    • Last Update: 2021-07-28
    • Source: Internet
    • Author: User
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    Patients with COVID-19 often suffer from liver damage
    .


    The clinical relevance of SARS-CoV-2 infection- related liver injury is not yet clear, and prospective analysis of the effects of abnormal baseline liver function testing (LFT) is needed


    COVID-19 infection

    Recently, a research article was published in Gut, an authoritative journal in the field of digestive diseases.
    Researchers prospectively included 217 patients with no previous liver disease from the COVID-19 registration center from LMU University Hospital for analysis, aiming to evaluate the liver at admission.
    The relationship between dysfunction and the course of COVID-19 disease
    .


    The course of severe illness is defined as admission to an intensive care unit (ICU) or death related to COVID-19


    digestion

    58% of COVID-19 patients have abnormal liver function at baseline, glutamyl aminotransferase (AST) (42%), gamma-glutamyl aminotransferase (GGT) (37%), alanine aminotransferase (ALT) (27) %) significantly increased, and 33% of patients had hypoalbuminemia
    .


    Elevated ALT and GGT and hypoalbuminemia are associated with a higher proportion of patients requiring ICU treatment and mechanical ventilation


    Receiver operating characteristic curve

    After adjusting for age, gender, and complications, the combination of hypoalbuminemia combined with AST or GGT abnormal hospitalization is ICU admission (OR 46.


    It can be seen that abnormal liver function at admission, especially GGT and albumin abnormalities, are related to the serious course of SARS-CoV-2 infection


    Abnormal liver function at admission, especially GGT and albumin abnormalities, are related to the severe course of SARS-CoV-2 infection patients

    Original source:

    Original source:

    Sabine Weber.


    Liver function test abnormalities at hospital admission are associated with severe course of SARS-CoV-2 infection: a prospective cohort study in this message
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