GUT: Alpha-1 antitase controls alcohol-related liver disease in mice and humans

Alcohol-related liver disease (ALD) is a global health care problem with limited treatment options.
alpha-1 antitestroteinase (AAT) has shown strong anti-inflammatory activity in many preclinical and clinical trials.
the study, researchers aim to explore the role of AAT in ALD.
researchers conducted clinical data collection on 512 patients with cirrhosis.
compared the survival time, clinical and bio-chemical parameters, including differences in AAT serum concentrations, in patients with ALD and other liver lesions.
evaluated the role of AAT in the experimental ALD model and verified it.
results showed a significantly higher risk of death/liver transplantation in patients with cirrhosis ALD with AAT serum concentrations below 120 mg / dL than in patients with AAT serum concentrations above 120 mg / dL.
multivarivation Cox regression analysis shows that low AAT serum concentration is an independent survival time factor.
liver AAT in ethanol-fed wild (wt) mice decreased significantly compared to paired-fed mice.
to test AAT's therapeutic ability, ethanol-fed wild mice were treated with human AAT.
AAT's dosing improved liver damage, neutral granulocyte immersion and fat degeneration.
increased risk of death/liver transplantation in patients with cirrhosis alD with AAT concentrations below 120 mg / dL.
, AAT levels can predict treatment options for human ALD, especially in patients with alcoholic hepatitis.