GUT: Bacteria in cancer cells, Sun Yat-sen University Zhang Ge team revealed the tumor bacteria promote cancer metastasis mechanism

A weighty paper has been published in the journal Science.
team at the Weizmann Institute of Science in Israel found that there are many bacteria in human tumor cells.
As early as more than 100 years ago, scientists detected bacteria in human tumors, which some believe suggests that bacteria may have localized effects in the micro-environment of the tumor, while others point out that they are so low that it is difficult to confirm whether they actually come from tumor samples or from external contamination.
the science paper analyzed seven common solid tumors, including breast, lung, melanoma and pancreatic cancer, with more than 1,500 samples.
analysis confirmed that most tumor samples contained bacteria.
, most of these bacteria are located in tumor cells! But the exact role of these bacteria in tumors is not clear.
November 11, 2020, a team of professors from Sun Yat-sen University's School of Pharmacy published a report entitled: Exosomes derived from Fusobacterium nucleocle in the internationally renowned academic journal Gut (IF-19.82). Research paper by atum-infected colorectal cancer cells helping to metastasis by selectively carrying miR-1246/92b-3p/27a-3p and CXCL16.
the study showed that OCS (F. nucleatum) was found to be rich in tumor tissue and stool samples in colorectal cancer patients, inducing tumor cells to produce a large number of miR-1246/92b-3p/27a-3p and CXCL16/RhoA/IL-8-rich exosomes, and further promoting cancer metastasis.
This research opens up a new field of infectious cell-specific exosomes in tumors, provides new insights into the molecular mechanism of carcinogenic bacterial-host interaction, and provides valuable ideas for clinical colorectal cancer treatment.
Professor Zhang Ge's team previously found that Ocythrobacteria, a co-cytobacterium that survives and proliferates in macrophages, was the first reported strict anaerobic cytobacteria, opening up new areas of research on survival within the host cells of strict anaerobic bacteria.
endocytobacterial infection can mediate changes in the host cell secretion exosome, which performs intercellular communication functions through the proteins, nucleic acids, lipids, and metabolites it carries, and participates in a variety of physiological and pathological processes.
years, the role of tumor cell secretion of exosomes in cancer has been clarified and analyzed, and the secretion of infectious exosomes by bacteria in tumors and their effect on tumors is still a new field.
the study found through multi-histological techniques: Bacillus difficile infected colorectal cancer cells, induced host cells to produce a large number of miR-1246/92b-3p/27a-3p and CXCL16 /RhoA/IL-8 rich exosomes, these tumors are both infectious and specific exosomes are transmitted to uninfected colorectal cancer cells in the micro-environment, through miRNA and protein multiple target molecules and multiple action patterns together to promote the metastasis of colorectal cancer.
This study opens up a new field of tumor-specific exosomes, provides new insights into the molecular mechanism of carcinogenic bacterial-host interactions, suggests that exosomes that are the source of C. difficile-infected colorectal cancer cells may be an important carcinogenic factor to promote the development and metastasis of colorectal cancer, and points out the importance of C. difficile removal in tumor treatment and provides valuable ideas for the treatment of clinical colorectal cancer.
Songhe, a doctoral student at Sun Yat-sen University's School of Pharmacy, is the first author, Chen Jun, Chen Fangfang is the second and third author, and Professor Zhang Ge is the correspondent.
study was supported by the National Natural Science Foundation of China and helped by Professor Liu Wanli of Sun Yat-sen University's Cancer Prevention and Control Center.