GUT: Changes in intestinal flora can exacerbate kidney failure in humans and rodents

BACKGROUND and Purpose: It has been found in animal studies that patients with kidney failure have symptoms caused by uremia toxins, which may be caused by gut microbesTherefore, the purpose of this study is to explore the relationship between the composition of the gut microbiome, uremia toxins and the symptoms of kidney failure in human end-stage nephropathy (ESRD)method: The researchers collected 223 ESRD patients and 69 healthy control populations of gut microbiome, serum and fecal metabolites, and human phenotypesCubes reveal the link between these data sets and the use of rodent models of chronic kidney disease (CKD) to test the effects of the gut microbiome on toxin accumulation and disease severityresults: microbes in ESRD patients are closely related to clinical outcomes and encode the functions involved in the synthesis of toxins and secondary bile acids; The microbiome in sterile mice transplanted to kidney damage or in antibiotic-treated rats induces higher serourets to increase the production of seromyuatia, exacerbating renal fibrosis and oxidative stress than the microbiome of the control groupNucleobacteria can improve the production of uremia toxins and promote the development of kidney disease to chronic kidney failureProbiotic sylobacteria can reduce the abundance of these species, reduce toxin levels and the severity of disease in ratsconclusion: ESRD patients intestinal flora abnormal, not conducive to clinical metabolism, suggesting that intestinal flora will become a target to reduce the clinical symptoms of uremia patients