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    Home > Active Ingredient News > Digestive System Information > GUT: Combination of vedolizumab and thiopurines has lower risk of failure in Crohn's disease than vedolizumab monotherapy

    GUT: Combination of vedolizumab and thiopurines has lower risk of failure in Crohn's disease than vedolizumab monotherapy

    • Last Update: 2022-05-09
    • Source: Internet
    • Author: User
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    Vedolizumab was the first biologic approved for the treatment of inflammatory bowel disease after the era of tumor necrosis factor antagonists (anti-TNF)


    Vedolizumab was the first biologic approved for the treatment of inflammatory bowel disease after the era of tumor necrosis factor antagonists (anti-TNF)


     

    The researchers screened patients with CD and UC identified for vedolizumab based on two national health care databases in the United States and France


    statistics

     

    Study results showed that among a total of 10,299 vedolizumab users, at week 26, 236 (29.


     

    In this study, we found that vedolizumab and thiopurine combination therapy had lower treatment failure rates in CD compared with vedolizumab monotherapy in two large cohorts, but not in UC.


    In this study, we found that vedolizumab and thiopurine combination therapy had lower treatment failure rates in CD compared with vedolizumab monotherapy in two large cohorts, but not in UC.


    Original source:

    Julien Kirchgesner.


    Julien Kirchgesner.
    et al.
    Decreased risk of treatment failure with vedolizumab and thiopurines combined compared with vedolizumab monotherapy in Crohn's disease.
    GUT.
    2022.
    Decresed risk of treatment failure with vedolizumab and thiopurines combined compared with vedolizumab monotherapy in Crohn's disease.


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