GUT: Does a high-fat diet affect sperm's ability to exercise?

In most people's impression, a high-fat diet can make people fat, in fact, in addition to getting fat, it may also cause you to suffer from infertility Oh! Infertility is a public health problem affecting about 10%-15% of couples of childbearing age worldwide, and the assessment and classification of male infertility depends on the analysis of their semen, which includes three parameters, namely sperm concentration, morphology and motorism.
data suggests that lifestyle may affect male fertility by altering the body's endocrine characteristics, sperm production and sperm function.
studies have shown that obese male mice are more likely to produce unhealthy offspring, and a recent study has shown that high-quality diets affect sperm production and motor skills by affecting gut microbiomes. In an experiment,
researchers transplanted gut microbes from a high-quality diet (HFD) into mice with a normal diet (ND) and found that sperm production and sperm vitality decreased significantly in mice fed ND, but similar transplants in mice fed ND did not make such a significant improvement.
analysis of the microbiome showed a significant increase in the genus Pycobacteria and Prevo's genus, both of which may have led to metabolic endotoxinemia in HFD-FMT mice.
interestingly, gut microorganisms from clinical subjects showed a negative correlation between the richness of the genus and genus Pylori and sperm movement, and a positive correlation between the genus endotoxin and the genus toxicobacteria.
HPD microbial transplantation also led to a significant increase in intestinal immersion of T-cells and macrophages, as well as inflammatory cytokines in the appendicle, suggesting that testicular inflammation is likely to lead to damage to sperm vitality.
RNA sequencing showed significantly reduced expression of those genes involved in match-subtransmeter division and testicular mitochondrial function in HFD-FMT mice.
: High-quality diet mouse feces transplanted to normal diet mice finally researchers said.
is a close relationship between microbiome disorders caused by high-quality diet (HFD) and sperm defects, elevated endotoxins, testicular gene expression disorders and localized testicular inflammation are potential causes.
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