GUT: Effect of fecal flora transplantation on patients with irritable bowel syndrome
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Last Update: 2020-06-22
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Source: Internet
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Author: User
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Background and Objective: Scholars have tried to treat disease from healthy donor to patients with irritable bowel syndrome (IBS) for fecal flora transplantation (FMT)The purpose of this study is to conduct more in-depth researchmethod: This study was a randomized, double-blind, placebo-controlled study in which researchers randomly divided 165 IBS patients into placebos (their own feces) and the experimental group (feces obtained from healthy individuals) of 30 g FMT or 60 g FMT, with a ratio of 1:1:1The main outcome was the reduction of IBS symptoms 3 months after FMTRelief is defined as a reduction of more than 50 points in the overall IBS symptom scoreThe secondary result was 1 month after FMT, with a reduction in the malnutrition index (DI) analyzed by 16S rRNA gene sequencing and a change in the distribution of gut bacteriaresults: 23.6%, 76.9% (p.0001) and 89.1% (p 00.0001) of patients receiving placebo, and 30 g FMT alloseform fecal transplants, respectivelyThere was a significant improvement in fatigue and quality of life in these patients receiving FMTThere were also significant changes in the intestinal bacterial characteristics of the FMT groupFMT adverse events are mild self-limiting gastrointestinal symptomsconclusion: FMT is an effective method for treating PATIENTs with IBSThe use of clear donors with normal DI and good specific microbial characteristics is essential for the successful implementation of FMT
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