GUT: Long-chain fatty acids and anti-inflammatory bacteria in the gut.

Clinical study data show that probiotics have a regulatory effect on colon inflammation, but the mechanism by which probiotics relieve colitis is not clear.
researchers recently identified and quantified levels of free long-chain fatty acids (LCFAs) in probiotics through mass spectrometry and assessed their effects on colitis in mice.
researchers conducted mass spectrometry studies of all LCFA produced by E. coli Nissle 1917, nissle 1917 produced a significant increase in concentrations of 3-hydroxyeene acid (C18-3OH) compared to other E. coli strains.
oral C18-3OH can reduce colitis in mice induced by sodium glucan sulfate.
also found that the anti-inflammatory properties of probiotic polyfructose (FOS) were associated with an increase in colon C18-3OH concentrations.
increase in the concentration of C18-3OH was associated with an increase in the abundance of mycobacteriums Allobaculum, Haldeman's bacteria, and Dystrophy.
Bholdemanella Bigois produces high concentrations of C18-3OH during culture.
using tr-fret binding tests and gene expression analysis to prove that C18-3OH is an exciting agent for activating the γ of peroxidase proliferators.
study found that gut bacteria producing 3-hydroxy-octoleic acid is an effective anti-inflammatory component that produces microbial/host interactions.
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