GUT: Long-term effectiveness analysis of stool immunochemical test for screening proximal and distal colorectal cancer

Colorectal cancer (CRC) is currently the fourth leading cause of cancer death in the world, and screening can effectively reduce its morbidity and mortality
.

Although endoscopic screening is the most effective method, its invasive shortcomings prevent it from being widely used

Colorectal cancer (CRC) is currently the fourth leading cause of cancer death in the world, and screening can effectively reduce its morbidity and mortality

 

Researchers conducted a prospective cohort study on the biennial FIT screening population across Taiwan
.

From 2004 to 2009, a total of 5417699 eligible subjects were invited to participate in the screening and follow-up until 2014

statistics

 

FIT screening (exposed and unexposed) reduced the incidence of advanced CRC (48.
4 vs 75.
7/100,000) and mortality (20.
3 vs 41.
3/100,000), and the incidence of advanced CRC (aRR=0.
66, 95% CI 0.
63 to 0.
70) ) And CRC deaths (aRR=0.
60, 95% CI 0.
57 to 0.
64) were statistically significantly reduced
.

FIT screening is more effective in reducing distal advanced CRC (aRR=0.

 

This biennial large-scale FIT screening based on a large population shows that receiving FIT screening can significantly reduce advanced CRC by 34%, reduce CRC deaths by 40%, and the long-term effectiveness of the distal colon is greater than that of the proximal colon
.

Differences in long-term effectiveness of specific sites also provide insight into remedies that are less effective in proximal colon FIT screening

This biennial large-scale FIT screening based on a large population shows that receiving FIT screening can significantly reduce advanced CRC by 34%, reduce CRC deaths by 40%, and the long-term effectiveness of the distal colon is greater than that of the proximal colon

Han-Mo Chiu.

Long-term effectiveness of faecal immunochemical test screening for proximal and distal colorectal cancers.
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