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Gut: Multi-omics reveals the unique characteristics of epidermal adipose tissue related to systemic insulin resistance

 Last Update: 2021-10-10
 Source: Internet
 Author: User

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Human white adipose tissue (AT) is a metabolically active organ with a unique storage-specific function
.

Despite their location close to the gastrointestinal tract, few studies have compared mesenteric AT with epidermal AT (epiAT)

Recently, a research article was published in Gut, an authoritative journal in the field of digestive diseases.
Researchers aim to summarize the characteristics of these ATs and estimate their effects on changes in systemic metabolism
.

Digestion

The researchers collected AT from 70 obese patients who underwent Roux-en-Y gastric bypass surgery
.

The cohort with well-defined metabolic characteristics included 9 insulin-sensitive (IS) obese subjects.

Although mesenteric AT exhibits similar characteristics to omental AT, epiAT differs from all other fat depots studied
.

Multi-omics allows a clear distinction between IS and IR status in all organizations

It can be seen that the multi-omics epiAT feature reflects a systemic IR and obesity subphenotype that is different from other fat depots
.

The data from this study indicate that human epidermal fat has a previously unrecognized role in the context of obesity, impaired insulin sensitivity and related diseases

The multi-omics epiAT feature reflects a systemic IR and obesity subphenotype that is different from other fat depots

Original source:

Laura Krieg.

Multiomics reveal unique signatures of human epiploic adipose tissue related to systemic insulin resistance in this message

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