Gut: Regular proton pump inhibitors with type 2 diabetes risk.

Although a recent randomized controlled trial showed a tendency to increase the risk of type 2 diabetes by using proton pump inhibitors (PPI), the link between regular PPI use and the risk of type 2 diabetes is unclear.
a recent study published in Gut, an authoritative journal in the field of digestive diseases, to assess the relationship between routine use of PPI and the risk of type 2 diabetes.
forward-looking analysis included 204,689 diabetes-free participants in the Nurses' Health Study (NHS), NHS II and Health Professional Follow-up Study (HPFS).
researchers used the American Diabetes Association's (ADA) diagnostic criteria to identify type 2 diabetes and assessed an adjusted risk ratio (HRs) based on demographic factors, lifestyle habits, complications, other drug use, and clinically adaptive disorders.
researchers recorded 10,105 cases of diabetes, followed by 2127,471 a year.
those who took PPI regularly had a 24 percent higher risk of developing diabetes than those who did not (HR was 1.24, 95 percent CI was 1.17 to 1.31).
duration of taking PPI increases the risk of diabetes.
compared to non-users, the fully adjusted HR of participants who took PPI for 0-2 years was 1.05 (95% CI was 0.93 to 1.19) and for participants who took PPI for more than 2 years was 1.26 (95% CI 1.18 to 1.35).
, regular PPI use was associated with a higher risk of type 2 diabetes and increased risk over time of use.
, physicians should take extra care when prescribing PPI, especially when using it for long periods of time.
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