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Proton pump inhibitors (PPI) are one of the top ten most commonly used drugs in the world.
PPI is commonly used for acid-related diseases such as gastroesophedic reflow disease, peptic ulcer disease and non-ulcerative indigestion.
generally believe that short-term use of PPI is safe.
, long-term use of PPI has been associated with adverse reactions such as fractures, chronic kidney disease, bowel infections and stomach cancer.
addition, type 2 diabetes has become a global epidemic, with a global prevalence rate of 8.5 per cent in 2014, and the causes of type 2 diabetes are complex and involve a variety of genetic, behavioural and environmental factors.
recent years, researchers have turned their attention to the role of human gut bacteria, which is critical to expanding the role of host metabolism in the development of diabetes.
the significant effects of PPI on the gut microbiome, its use may be associated with an increased risk of type 2 diabetes.
study aims to assess the regular use of PPI and the risk of type 2 diabetes.
researchers conducted a retrospective study of 204,689 non-diabetic participants.
confirmed the onset of type 2 diabetes using the American Diabetes Association's (ADA) diagnostic criteria.
then assessed the effects of demographic factors, lifestyle habits, complications, and other drug use on the risk of developing type 2 diabetes.
study recorded 10,105 cases of diabetes, and after follow-up of 2127,471 people, the risk of diabetes was 24% higher for the average PPI user than for non-users (HR 1.24, 95% CI 1.17 to 1.31).
duration of taking PPI increases the risk of diabetes.
1.05 (95% CI 0.93 to 1.19) for participants who used PPI greater than 2 years compared to non-users.
, the researchers confirmed that regular use of PPI was associated with a higher risk of type 2 diabetes and increased risk over time.
, physicians should take extra care when prescribing PPI, especially when using it for long periods of time.
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