Gut: The impact of different antibiotics on the risk of drug resistance in patients with inflammatory bowel disease during anti-TNFα treatment​

Anti-tumor necrosis factor (anti-TNF) monoclonal antibody is an effective and mature treatment method for alleviating Crohn's disease and ulcerative colitis

The occurrence of ADA is related to the decrease of serum drug level, the decrease of curative effect and the failure of treatment

Recently, it has been noted that there is a correlation between the composition of the gut microbiota and the response to anti-TNF treatments

The researchers analyzed data from epi-IIRN (the epidemiology group at the core of the Israeli IBD research), which is a national register of all IBD patients in Israel

Kaplan-Meier curve diagram of the cumulative risk of ADA development caused by the use of different types of antibiotics

The results showed that among the 1946 eligible patients, the median follow-up time from the start of treatment was 651 days, and 363 were ADA positive

Therefore, this study shows that the production of ADA is related to the composition of microorganisms

Original source:

Yuri Gorelik et al.