echemi logo
Product
  • Product
  • Supplier
  • Inquiry
    Home > Active Ingredient News > Digestive System Information > Gut: Use gut beneficial bacteria to open the "intestinal-brain axis" to restore glucose metabolism.

    Gut: Use gut beneficial bacteria to open the "intestinal-brain axis" to restore glucose metabolism.

    • Last Update: 2020-10-27
    • Source: Internet
    • Author: User
    Search more information of high quality chemicals, good prices and reliable suppliers, visit www.echemi.com
    Today, type 2 diabetes, a metabolic disease, is becoming more common.
    , according to a new report released last year by the International Diabetes Federation (IDF), there are at least 463 million people with diabetes worldwide (one in 11).
    the latest data on diabetes epidemiology in China in 2020, the total number of diabetics in China has reached 129.8 million.
    although the patient population is large, the current treatment for diabetes is no more than oral anti-sugar drugs and insulin injections.
    , scientists have been looking for ways to develop new treatments, and effective and side-effect-free oral therapies are a top priority.
    a recent study published in Gut, an international team led by France's National Institute of Health and Medical Research (INSERM) showed they were one step closer to developing the treatment.
    they used probiotics to regulate the role of intestinal bacteria in changing the role of intestinal neurons, thereby reducing hyperglycemia in diabetic mice.
    new study builds on previous studies that showed that fat molecules produced by beneficial bacteria in the gut can improve blood sugar metabolism.
    lipids are thought to affect the intestinal-brain axis, a key two-way communication between the brain and the highly developed intestinal nervous system (also known as the second brain).
    the intestinal nervous system plays a key role in controlling the intestinal-brain axis under normal and pathological conditions.
    in type 2 diabetes, communication between the intestines and the brain is interrupted, and then it happens: after a meal, the brain is unable to send signals to the liver, muscles and adipose tissue to tell them to absorb more glucose from the blood.
    results lead to insulin resistance.
    , the heteroential tract (the first part of the small intestine) sends signals to the brain, a process that involves the relaxation of the smooth muscles of the intestine.
    , however, in people with type 2 diabetes, these muscles show a continuous mechanical contraction or excessive contraction, resulting in signal disruption.
    believe that gut beneficial bacteria are key to reversing excessive contraction of the smooth intestinal muscle and restoring healthy glucose metabolism.
    known to promote the growth of beneficial bacteria, which improve glucose metabolism by producing a variety of lipids.
    , however, the identity of these lipids is still unknown.
    , the researchers fed the mice a special food with FOS.
    then compared the components in the colons of mice that had not been supplemented with FOS.
    found that although FOS probiotics ferment in the lower part of the intestine, they can function far from the colon.
    significant increase in the colons of mice treated with FOS was a lipid called 12-hydroxy-20 carbon tetraoleic acid (12-HETE).
    when they fed diabetic mice with 12-HETE, they not only reduced the excessive contraction of the hetero-fingers, but also improved blood sugar levels in the mice.
    to see if the results were applicable to humans, the team also analyzed biopsies of type 2 diabetes patients and healthy volunteers who had been treated with antidiabetics.
    found that levels of 12-HETE in the 12-fingered intestines of diabetics dropped by 38 percent compared to healthy volunteers.
    the findings were not statistically significant, but noted that the number of volunteers in their study was small.
    , they found that 12-HETE reduced muscle contraction in the heterointestinal tract by enhancing signals from mu opioids, a neurotransitor, thus restoring communication between the intestine and the brain.
    study is one of the latest to reveal the close relationship between human gut bacteria and our health.
    scientists are optimistic that their work will lead to new treatments that can boost the production of 12-HETE in the gut or supplement it with oral lipids.
    combined nutritional and pharmacological methods, we have identified a new way of communicating between gut microbes and hosts," the researchers concluded in their paper.
    , we have also discovered new targets and their mechanisms of role in rodents, which may also apply to humans.
    specific targets for treating type 2 diabetes and its complications will be a breakthrough solution for developing side-effect-free drugs.
    "
    This article is an English version of an article which is originally in the Chinese language on echemi.com and is provided for information purposes only. This website makes no representation or warranty of any kind, either expressed or implied, as to the accuracy, completeness ownership or reliability of the article or any translations thereof. If you have any concerns or complaints relating to the article, please send an email, providing a detailed description of the concern or complaint, to service@echemi.com. A staff member will contact you within 5 working days. Once verified, infringing content will be removed immediately.

    Contact Us

    The source of this page with content of products and services is from Internet, which doesn't represent ECHEMI's opinion. If you have any queries, please write to service@echemi.com. It will be replied within 5 days.

    Moreover, if you find any instances of plagiarism from the page, please send email to service@echemi.com with relevant evidence.