GUT: Western diets can affect necrotitis mortality.

The global incidence of acute pancreatitis (AP) is 33.74 cases per 100,000 people, of which there is a 1.6 risk of death per 100,000 people per year.
caused by acute pancreatitis are often debilitating and are the leading cause of death in these patients.
bacterialemia is a risk factor for necrotized pancreatitis, and previous studies have shown that increased permeability of the intestinal barrier and changes in the intestinal bacteria are associated with infection complications.
In this study, the researchers hypothesized that changes and functions in the gut microbiome could be identified that predate the onset of acute pancreatitis and predict the onset of acute necrotized pancreatitis (ANP), further analyzing whether the Western diet would exacerbate this effect.
the researchers fed the mice for four weeks on a standard food or Western diet, and then induced them to take taurine bileate to build a necrotized pancreatitis model.
collect blood and pancreas for bacteriological and immunological analysis.
used 16S rRNA gene amplification sequences to analyze the composition of the blind intestine microbiome in mice and to analyze blind intestine content metabolites through targeted and non-targeted metabolomics.
The preventive effects of necrotized pancreatitis in the model were compared between fecal microbial microbiome transplantation (FMT), terratin-negative antibiotic de-contamination, and oral or systemic butyric acid dosing in healthy mice.
results found that the mortality rate, systemic inflammation and bacterial transmission of mice fed to western diets increased, and their gut microbiome was characterized by loss of diversity, E. coli reproduction and butyric acid depletion.
although antibiotic de-contamination reduces mortality, the diffusion of Terrain-positives has increased.
oral and systemic butyric acid supplementation reduced mortality, and in the end, patients with acute pancreatitis showed an increase in the Proteobacteria bacteria and a decrease in the production of butyric acid bacteria compared to healthy subjects.
, the researchers concluded that Western-style diets have a negative effect on acute pancreatitis, and that timely butytate supplementation can play an important role in slowing the progression of the disease to necrotized pancreatitis.
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