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    Home > Biochemistry News > Biotechnology News > GVM (Genome Variation Map), the country's first and largest library of genome sequence variations

    GVM (Genome Variation Map), the country's first and largest library of genome sequence variations

    • Last Update: 2020-08-21
    • Source: Internet
    • Author: User
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    Recently, the Beijing Genomics Research Institute of the Chinese Academy of Sciences, the Large Data Center for Life and Health, developed the world's leading, the largest genome sequence variant library - GVM (Genome Variation Map).
    The library integrates a large number of genomic sequence single nucleotide polymorphic sites and small insertion and deletion variation information from multiple species based on manual validation, and is a resource bank for the intersection, management and retrieval of genomic sequence variation information.
    research by Genome Map:a data of the genome of the genome of the genome s in the Large Big Data Center, published online in nucleic Acids Research.
    genome sequence variation is the genetic variation of genomic DNA level, the basis of biodiversity, and the most valuable genetic resource for the study of species evolution, molecular breeding, good character selection and human disease.
    in recent years, with the development of sequencing technology, the genomes of more and more species have been analyzed finely, and genetic polymorphism sites within species have been obtained through large-scale population sequencing, and are widely used in the correlation analysis of complexity patterns.
    dbSNP and EVA, two of the world's largest data centers, NCBI and EBI, are the main repositories of genomic sequence variation.
    May this year, the NCBI announced that from 1 September 2017, dbSNP and dbVar will stop receiving non-character SNP submissions and from 1 November 2017 to stop non-character SNP online enquiries and submissions.
    this is inconvenient for researchers based on sequence variation.
    to this end, GVM, as one of the core data repositories of the Big Data Center for Life and Health, collected raw data for genome-wide sequence variation detection using second-generation sequencing and chip technology as the main means of detection, and obtained 19 species, including humans, livestock, major crops and other resource species, through standardized variation location identification and annotation. The species had about 5 billion mutant information, 8,884 individual genotype data, and 13,262 high-quality non-character species genotype and dedicate knowledge data were manually compiled, integrating knowledge information on 180,911 human variation sites.
    , giant pandas, killer whales, bamboo, rubber, wheat are unique species in GVM database.
    GVM has developed friendly data submission, browsing, search and visualization capabilities.
    users can retrieve the variation site information and download data through genomic location, mutation effect, gene name and gene function, etc., download the full gene variation information in the VCF and FASTA file formats through the ftp service, and submit data to the system online or offline, which facilitates the sharing of data by researchers.
    research has received financial support from the Chinese Academy of Sciences' Strategic Leading Science and Technology Project, the Chinese Academy of Sciences International Science Program, the National Science and Technology Research Program, the National High-Tech Research and Development Program (863 Plan), the National Nature Fund Project, the Chinese Academy of Sciences 100 People's Program, and the Chinese Academy of Sciences Youth Innovation Promotion Association.
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