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Overcoming acquired drug resistance is a major challenge in cancer treatment
The acquired resistance of cancer cells to treatment is a major challenge in patient management and treatment
Skin metastatic melanoma (CMM) is the deadliest skin cancer
Studies on the resistance of melanoma to vermolafenib or daprafenib (BRAFV600E inhibitor) and MEK inhibitors have revealed highly heterogeneous processes, most of which lead to the reactivation of MAPK signaling
In addition to affecting resistance, metabolism also profoundly affects the development of primary tumors
Heat map of A375R#1 and A375R#2 cell death induced by HA 344 and Vemu
Image source: https://pubmed.
In this study, the authors used a chemical procedure to generate derivatives of 5-aminoimidazole-4-carboxamide ribonucleotide, an AMPK activator and energy balance disruptor
references
Marwa Zerhouni et al.