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Dushan Wadduwage uses lasers for deep tissue imaging research in his northwestern laboratory
Scientists hope it will allow them to see the inner workings of complex systems
For a long time, microscopists have been looking for a way to perform high-quality deep tissue imaging of living bodies in a timely manner
Experts say that a better imaging system will have a powerful impact on researchers in biology and neuroscience
In this paper, the team proposed a new method that uses computational imaging to obtain high-resolution images 100 to 1000 times faster than other advanced technologies that use complex algorithms and machine learning
This system is called "Excited Mode Backscatter" (DEEP) and is considered the first of its kind, and may one day lead to a new understanding of the function of complex processes (such as those in the brain), because DEEP can capture images that other microscopes cannot capture
Because the new system has the potential to speed up how they can image and how quickly they can do it, "scientists process images quickly before they can capture, such as when a neuron is stimulated or how to move signals in the brain," Wadduwage said
The working principle of the system is similar to many other animal imaging techniques
There are two main ways to shoot such images
DEEP-TFM imaging of the cortical vascular system 100um below the surface
Courtesy of Dushan N.
However, DEEP allows large-scale and rapid tissue penetration and produces high-resolution images
DEEP is still in the early stages of development, but has come out of the proof-of-concept stage
Wadduwage said: "We showed that we can image about 300 microns in the brain of a living mouse
