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▎ WuXi AppTec's content team edits ultra-processed foods, such as sausages, meatballs, French fries, instant noodles, fried chicken nuggets, biscuits, instant soups, carbonated drinks.
.
.
are foods that many people love but are harmful to health
.
Many previous studies have found that eating ultra-processed foods is associated with increased risk of breast cancer, type 2 diabetes, cardiovascular disease and death
.
Recently, a study published in "Clinical Gastroenterology and Hepatology" (Clinical Gastroenterology and Hepatology) added new evidence that ultra-processed foods are harmful to health
.
Research results show that eating ultra-processed foods is associated with an increased risk of inflammatory bowel disease
.
Inflammatory bowel disease, including ulcerative colitis and Crohn's disease, is a group of chronic non-intestinal inflammatory diseases with unclear etiology
.
Under the action of a variety of factors, the patient's intestinal immune imbalance and persistent inflammatory damage to the intestinal mucosa
.
Former Japanese Prime Minister Shinzo Abe suffered from ulcerative colitis for a long time, and severe abdominal pain and diarrhea occurred during the attack.
Both of his resignations as prime minister were related to the disease
.
Image source: 123RF from Harvard Medical School (Harvard Medical School) and Massachusetts General Hospital (Massachusetts General Hospital) and other institutions, analyzed the data of three cohort studies in the United States, a total of 245112 subjects were included , They are between 25-75 years old and 83% are women
.
At the beginning of the study, the subjects’ age, gender, height, weight, physical activity, alcohol consumption, smoking status, and drug use information such as non-steroidal anti-inflammatory drugs and oral contraceptives were collected
.
At the same time, the consumption of different foods of the subjects was also collected, including unprocessed or minimally processed foods; processed foods for cooking; processed foods; and ultra-processed foods
.
After the start of the study, subjects will be followed up every 2-4 years to update basic health information and life>
.
Statistics found that subjects who consumed higher amounts of ultra-processed foods tended to have higher body mass index (BMI), higher total energy intake, and less physical activity
.
During the average follow-up period of 22 years, a total of 857 new cases of inflammatory bowel disease occurred, including 488 cases of ulcerative colitis and 369 cases of Crohn's disease.
The incidence rates were 6.
7/100,000-years and 8.
9/10, respectively.
10,000-years
.
After adjusting for the influence of other factors, the researchers found that eating ultra-processed food and the risk of inflammatory bowel disease increased, especially Crohn's disease
.
Compared with the 1/4 subjects who consumed the least amount of ultra-processed food (the energy intake of ultra-processed food accounted for about 21% of the total energy intake), the 1/4 subjects who consumed the highest amount of ultra-processed food (energy intake of ultra-processed food) Intake accounted for about 46.
4% of total energy intake), the risk of Crohn’s disease increased by 70%; the risk of ulcerative colitis increased by 20%
.
In addition, different types of ultra-processed foods have different effects on the increased risk of Crohn's disease
.
Ultra-processed breads and breakfast foods; ready-to-eat or hot foods; sauces, cheeses and creams have the most significant impact on the increased risk of Crohn’s disease
.
Image source: 123RF researchers analyzed that ultra-processed food may affect the risk of inflammatory bowel disease through a variety of mechanisms
.
First, a higher consumption of ultra-processed foods will reduce the consumption of fresh, unprocessed foods rich in dietary fiber and other nutrients, which will have an adverse effect on health; secondly, ultra-processed foods contain additives that may promote intestinal inflammation.
Such as sodium chloride; third, artificial sweeteners in ultra-processed foods may increase the risk of intestinal inflammation; fourth, emulsifiers, thickeners and other additives in ultra-processed foods may also directly Lead to intestinal inflammation; finally, nanoparticles contained in ultra-processed foods, such as titanium oxide, may also increase the susceptibility to inflammatory bowel disease
.
However, the mechanisms by which ultra-processed foods increase inflammatory bowel disease and the effects of different types of ultra-processed foods on the risk of Crohn’s disease and ulcerative colitis are still unclear, and further research is needed
.
Since the study is an observational study, it only shows the association between frequent consumption of ultra-processed foods and the risk of inflammatory bowel disease, and does not indicate a causal relationship
.
And the study also has some limitations.
For example, the subjects' diet depends on recall, which may also affect the results of the study
.
Picture source: The 123RF study finally pointed out that the incidence of inflammatory bowel disease is rising globally, partly because of changes in life>
.
"Our research results provide strong epidemiological support for the role of ultra-processed food in the occurrence of inflammatory bowel disease
.
Reducing and avoiding the consumption of ultra-processed food will help reduce the occurrence and prevalence of inflammatory bowel disease.
Promote the improvement of overall health"
.
It is recommended to read what the brain is doing while sleeping? How to make full use of the benefits of sleep? From "superhero Panthers" to "anti-cancer blogger A Jian", there are more and more young people suffering from colorectal cancer.
What should I do? The three major misunderstandings of body fat and blood fat, everyone should know to prevent stroke and eat peanuts? With 4-5 tablets per day, the risk of stroke may be reduced by 16%.
Shanghai Ruijin Hospital Research: These 12 risk factors increase the risk of diabetes! How many kinds do you have? References[1] Chun-Han Lo, et al.
,(2021).
Ultra-processed Foods and Risk of Crohn's Disease and Ulcerative Colitis: A Prospective Cohort Study.
Clinical Gastroenterology and Hepatology, DOI: https://doi.
org /10.
1016/j.
cgh.
2021.
08.
031.
[2] Dietary Interventions May Prove Helpful in Curbing Development of Crohn's Disease.
Retrieved Sep 17, 2021, from https:// -disease/94513 [3] Ge Junbo, Xu Yongjian, Wang Chen.
Internal Medicine [M].
9th edition.
Beijing: People's Medical Publishing House, 2018.
Disclaimer: WuXi AppTec content team focuses on introducing global biomedical health research progress
.
This article is for the purpose of information exchange only.
The opinions expressed in the article do not represent the position of WuXi AppTec, nor does it mean that WuXi AppTec supports or opposes the views in the article
.
This article is not a treatment recommendation either
.
If you need guidance on the treatment plan, please go to a regular hospital for treatment
.
.
.
are foods that many people love but are harmful to health
.
Many previous studies have found that eating ultra-processed foods is associated with increased risk of breast cancer, type 2 diabetes, cardiovascular disease and death
.
Recently, a study published in "Clinical Gastroenterology and Hepatology" (Clinical Gastroenterology and Hepatology) added new evidence that ultra-processed foods are harmful to health
.
Research results show that eating ultra-processed foods is associated with an increased risk of inflammatory bowel disease
.
Inflammatory bowel disease, including ulcerative colitis and Crohn's disease, is a group of chronic non-intestinal inflammatory diseases with unclear etiology
.
Under the action of a variety of factors, the patient's intestinal immune imbalance and persistent inflammatory damage to the intestinal mucosa
.
Former Japanese Prime Minister Shinzo Abe suffered from ulcerative colitis for a long time, and severe abdominal pain and diarrhea occurred during the attack.
Both of his resignations as prime minister were related to the disease
.
Image source: 123RF from Harvard Medical School (Harvard Medical School) and Massachusetts General Hospital (Massachusetts General Hospital) and other institutions, analyzed the data of three cohort studies in the United States, a total of 245112 subjects were included , They are between 25-75 years old and 83% are women
.
At the beginning of the study, the subjects’ age, gender, height, weight, physical activity, alcohol consumption, smoking status, and drug use information such as non-steroidal anti-inflammatory drugs and oral contraceptives were collected
.
At the same time, the consumption of different foods of the subjects was also collected, including unprocessed or minimally processed foods; processed foods for cooking; processed foods; and ultra-processed foods
.
After the start of the study, subjects will be followed up every 2-4 years to update basic health information and life>
.
Statistics found that subjects who consumed higher amounts of ultra-processed foods tended to have higher body mass index (BMI), higher total energy intake, and less physical activity
.
During the average follow-up period of 22 years, a total of 857 new cases of inflammatory bowel disease occurred, including 488 cases of ulcerative colitis and 369 cases of Crohn's disease.
The incidence rates were 6.
7/100,000-years and 8.
9/10, respectively.
10,000-years
.
After adjusting for the influence of other factors, the researchers found that eating ultra-processed food and the risk of inflammatory bowel disease increased, especially Crohn's disease
.
Compared with the 1/4 subjects who consumed the least amount of ultra-processed food (the energy intake of ultra-processed food accounted for about 21% of the total energy intake), the 1/4 subjects who consumed the highest amount of ultra-processed food (energy intake of ultra-processed food) Intake accounted for about 46.
4% of total energy intake), the risk of Crohn’s disease increased by 70%; the risk of ulcerative colitis increased by 20%
.
In addition, different types of ultra-processed foods have different effects on the increased risk of Crohn's disease
.
Ultra-processed breads and breakfast foods; ready-to-eat or hot foods; sauces, cheeses and creams have the most significant impact on the increased risk of Crohn’s disease
.
Image source: 123RF researchers analyzed that ultra-processed food may affect the risk of inflammatory bowel disease through a variety of mechanisms
.
First, a higher consumption of ultra-processed foods will reduce the consumption of fresh, unprocessed foods rich in dietary fiber and other nutrients, which will have an adverse effect on health; secondly, ultra-processed foods contain additives that may promote intestinal inflammation.
Such as sodium chloride; third, artificial sweeteners in ultra-processed foods may increase the risk of intestinal inflammation; fourth, emulsifiers, thickeners and other additives in ultra-processed foods may also directly Lead to intestinal inflammation; finally, nanoparticles contained in ultra-processed foods, such as titanium oxide, may also increase the susceptibility to inflammatory bowel disease
.
However, the mechanisms by which ultra-processed foods increase inflammatory bowel disease and the effects of different types of ultra-processed foods on the risk of Crohn’s disease and ulcerative colitis are still unclear, and further research is needed
.
Since the study is an observational study, it only shows the association between frequent consumption of ultra-processed foods and the risk of inflammatory bowel disease, and does not indicate a causal relationship
.
And the study also has some limitations.
For example, the subjects' diet depends on recall, which may also affect the results of the study
.
Picture source: The 123RF study finally pointed out that the incidence of inflammatory bowel disease is rising globally, partly because of changes in life>
.
"Our research results provide strong epidemiological support for the role of ultra-processed food in the occurrence of inflammatory bowel disease
.
Reducing and avoiding the consumption of ultra-processed food will help reduce the occurrence and prevalence of inflammatory bowel disease.
Promote the improvement of overall health"
.
It is recommended to read what the brain is doing while sleeping? How to make full use of the benefits of sleep? From "superhero Panthers" to "anti-cancer blogger A Jian", there are more and more young people suffering from colorectal cancer.
What should I do? The three major misunderstandings of body fat and blood fat, everyone should know to prevent stroke and eat peanuts? With 4-5 tablets per day, the risk of stroke may be reduced by 16%.
Shanghai Ruijin Hospital Research: These 12 risk factors increase the risk of diabetes! How many kinds do you have? References[1] Chun-Han Lo, et al.
,(2021).
Ultra-processed Foods and Risk of Crohn's Disease and Ulcerative Colitis: A Prospective Cohort Study.
Clinical Gastroenterology and Hepatology, DOI: https://doi.
org /10.
1016/j.
cgh.
2021.
08.
031.
[2] Dietary Interventions May Prove Helpful in Curbing Development of Crohn's Disease.
Retrieved Sep 17, 2021, from https:// -disease/94513 [3] Ge Junbo, Xu Yongjian, Wang Chen.
Internal Medicine [M].
9th edition.
Beijing: People's Medical Publishing House, 2018.
Disclaimer: WuXi AppTec content team focuses on introducing global biomedical health research progress
.
This article is for the purpose of information exchange only.
The opinions expressed in the article do not represent the position of WuXi AppTec, nor does it mean that WuXi AppTec supports or opposes the views in the article
.
This article is not a treatment recommendation either
.
If you need guidance on the treatment plan, please go to a regular hospital for treatment
.
