HBP: White matter degeneration in the distal brain area of ​​patients with stroke basal ganglia damage and movement disorders

Focal brain injury can affect the overall performance of the brain network
.

In the past few decades, many neuroimaging studies using magnetic resonance imaging (MRI) have investigated the structural and functional reorganization after stroke

Focal brain injury can affect the overall performance of the brain network

Yijing Guo et al.

Diagram of the incidence of lesions in stroke patients
.

The stroke lesion is projected to the left hemisphere and covered on the T1 template in the standard MNI space

Diagram of the incidence of lesions in stroke patients

The DTI data is processed to obtain partial anisotropy (FA) maps, and multivariate pattern analysis is performed based on the FA maps to explore brain regions that play an important role in classification

Multivariate pattern analysis (MVPA) classification results
.

Use the fractional anisotropy (FA) diagram of the diffusion tensor imaging (DTI) data to classify stroke patients and the control group (a) and the receiver operating characteristic (ROC) curve (b) to compare its accuracy 100% (sensitivity is 100%, specificity is 100%), statistical significance is P<.

Multivariate pattern analysis (MVPA) classification results

Whole brain voxel weight map
.

It shows that the white matter area based on the fractional anisotropy (FA) value helps to distinguish between groups

Whole brain voxel weight map

The subnet determined by network statistics (NBS) analysis
.

(a,b) Compared with the control group, stroke patients have fewer sub-network connections

The subnet determined by network statistics (NBS) analysis
.
(a,b) Compared with the control group, stroke patients have fewer sub-network connections
.
The connections of the sub-networks shown in the brain model (a) and circle (b)
.

In addition to the well-known concept of lesion-symptom mapping, some lesions located in a single location in the brain may disrupt brain function and transmit it to a wide range of neural networks
.
The study confirmed that local damage to
the basal ganglia may affect the distal regions of the brain .
The pattern of WM degeneration affecting the distal brain area of ​​the lesion was determined, and the abnormal organization of the structural network of stroke patients was revealed, which may help to understand the neural mechanism of hemiplegia
.

In addition to the well-known concept of lesion-symptom mapping, some lesions located in a single location in the brain may disrupt brain function and transmit it to a wide range of neural networks
.
The study confirmed that local damage to
the basal ganglia may affect the distal regions of the brain .
The pattern of WM degeneration affecting the distal brain area of ​​the lesion is determined, and the abnormal organization of the structural network of stroke patients is revealed .
The local destruction of the basal ganglia may affect the distal area of ​​the brain
.
The pattern of WM degeneration affecting the distal brain area of ​​the lesion was determined, and the abnormal organization of the structural network of stroke patients was revealed, which may help to understand the neural mechanism of hemiplegia
.

Original source

Original source

White matter degeneration in remote brain areas of stroke patients with motor impairment due to basal ganglia lesions.
https://doi.
org/10.
1002/hbm.
25583

White matter degeneration in remote brain areas of stroke patients with motor impairment due to basal ganglia lesions.
https://doi.
org/10.
1002/hbm.
25583 https://doi.
org/10.
1002/hbm.
25583 Leave a message here