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    Home > Active Ingredient News > Endocrine System > Health can also be passed from person to person, study shows spouses of longer-lived people have lower risk of diabetes

    Health can also be passed from person to person, study shows spouses of longer-lived people have lower risk of diabetes

    • Last Update: 2022-06-14
    • Source: Internet
    • Author: User
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    Edited by Yimaitong, please do not reprint without permission


    Results from the Multicenter Cohort Longevity Family Study (LLFS), led by the University of Pittsburgh Graduate School of Public Health in Pittsburgh, Pennsylvania, were recently published in Frontiers in Clinical Diabetes and Healthcare

    The study included follow-up of 582 families

    In these 582 households, at least one parent lived 90 years or older

    The findings suggest that offspring and spouses of long-lived individuals may have an equally lower risk of developing type 2 diabetes than the general population, especially in middle age

    Children/Spouses of Long Lives Have Lower Risk of Type 2 Diabetes In the LLFS study, investigators followed 583 families from Boston, New York, Pittsburgh, and Odense, Denmark between 2014 and 2017

    Of the 1,585 offspring and 495 mates who did not have diabetes at the start of the study, 3.
    7% of the offspring and 3.
    8% of the mates developed type 2 diabetes during follow-up


    The overall annual incidence was 4.
    6 offspring/1000 person-years and 4.
    7/1000 person-years in spouses, and increased with age at baseline: 3.
    6/1000 and 3.
    0/1000 in 45-64 year olds 1,000 person-years; when increasing to age 65 and older, the numbers increased to 7.
    2 cases/1,000 person-years and 7.
    4 cases/1,000 person-years, respectively


    For reference, recent data indicate that in the general U.
    adult population, the overall incidence of type 2 diabetes is 6.
    9 cases/1000 person-years, 9.
    9 cases/1000 person-years 45-64 years old, and 8.
    8 cases/1000 person-years 65 years and older 1000 person-years


    Risk factors for type 2 diabetes in offspring/spouse of long-lived persons In the offspring of long-lived persons included in the study, the odds of developing type 2 diabetes increased with baseline BMI (OR: 2.
    55, P<0.
    0001), waist circumference (OR: 2.
    52, P<0.
    0001) and fasting serum triglycerides (OR: 1.
    56, P=0.
    0042); at the same time, with HDL cholesterol (OR: 0.
    56, P<0.
    0042), adiponectin (OR: 0.
    60, P<0.
    0024) and sex hormone binding globulin (OR: 0.
    55, P < .
    0019) decreased


    A similar association was found among the spouses of long-lived people

    With the exception of sex hormone-binding globulin, which did not show a significant association, increases in free interleukin-6 (OR: 1.
    63, P=0.
    048) and insulin-like growth factor-1 (OR: 1.
    79, P=.
    04) were both associated with more associated with a higher incidence of type 2 diabetes



    Similar associations were found among spouses, but not with sex hormone-binding globulin, and two other factors increased the risk of type 2 diabetes: circulating interleukin-6 (OR, 1.
    63; P=.
    048) and insulin-like Growth factor 1 (OR, 1.
    79; P=.


    The possible mechanism of this phenomenon The researchers believe that the occurrence of this phenomenon may be related to genetics, epigenetics and common environmental factors

    For example, it is common for couples living together to have similar life>

    In addition, the researchers noted that mates were more likely to engage in physical activity and drink alcohol in moderation than offspring

    Both of these life>

    Thus, protective familial genetic and biological factors may influence glucose homeostasis in offspring, and among their spouses, healthier life>

    At the same time, the authors also propose another possible explanation: people unconsciously tend to choose their partners through the so-called "clustering" principle, that is, people may be more inclined to choose phenotypes and genotypes similar to their own.
    people as spouses, and this includes those genotypes that affect diabetes risk and longevity


    References: [1]Miljkovic I, Cvejkus R, An P, et al.
    Low risk for developing diabetes among the offspring of individuals with exceptional longevity and their spouses[J].
    Frontiers in Clinical Diabetes and Healthcare, 25.

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