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There is currently no drug to stop the progression of abdominal aortic aneurysm (AAA).
Recently, a research paper published in Heart, an authoritative journal in the field of cardiology, evaluated and meta-analyzed data from previously published randomized controlled trials that assessed the efficacy of antidepressants and antibiotics in blocking AAA progression and AAA-related events, i.e. rupture or repair.
conducted systematic literature searches to determine randomized controlled trials that assessed the efficacy of blood pressure-lowering drugs or antibiotics in reducing AAA progression and AAA-related events.
AAA growth (mm/year) with ultrasound or computer fault scanning imaging.
researchers used random effect models for meta-analysis and subgroup analysis with trials of tetrycline or large-ring endoester antibiotics.
the study included 10 randomized controlled trials involving 2,045 asymptomatic AAA participants.
follow-up period is 18 to 63 months.
use of blood pressure-lowering drugs (average increase± SD 2.0±2.4 vs 2.3±2.7 mm/year; Standard Average Difference (SMD) -0.07,95% CI -0.19 to 0.06; p=0.288) and antibiotics (both growing±SD 2.6±2.1 vs.2.6±2.5mm/year; SMD-0.11, 95% CI is -0.38 to 0.16; p-0.418) does not slow down AAA progress or AAA-related events (anti-stress drugs: 92 vs 95 events; risk ratio (RR) is 0.86, 95% CI is 0.66 to 1.11; p-0.244; Antibiotics: 69 vs 73 events; RR is 0.93, 95% CI is 0.69 to 1.25; p=0.614).
results were obtained from a subgroup analysis of antibiotics.
meta-analysis showed that between anti-depressants or antibiotics did not prevent progression or clinically relevant events in AAAs patients.