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Graves' disease (GD) can both aggravate pre-existing heart disease and cause new heart failure (HF), but large studies are lacking
.
Recently, a research article was published in Heart, an authoritative journal in the field of heart disease.
The study retrospectively included GD (2009-2019) patients
.
Heart failure with reduced ejection fraction (HFrEF) is defined as left ventricular ejection fraction <50% and meets Framingham criteria, while heart failure with normal ejection fraction (HFpEF) is defined as meets HFA-PEFF criteria
In HFpEF patients, independent risk factors include chronic obstructive pulmonary disease (HR of 7.
2 (3.
5-14.
6), p<0.
001), older age (HR of 1.
5 (1.
2-2.
0) per 10 years, p=0.
001), Significant hyperthyroidism (HR of 6.
4 (1.
5–27.
1), p=0.
01), high body mass index (BMI) (HR of 1.
07 (1.
03–1.
10) per unit, p=0.
001), and hypertension (HR of 3.
1) (1.
3–7.
2), p=0.
008)
.
HFrEF (HR was 10.
Heart blood vessels 5.
4% of GD patients with new-onset HF, and cardiovascular hospitalization and death associated with an increased risk, the risk factors include atrial fibrillation, higher TRAb, significantly higher BMI and hyperthyroidism
Original source:
Jwan A Naser.
et al.
Incidence, risk factors, natural history and outcomes of heart failure in patients with Graves' disease in this message
