Heart: Incidence, risk factors, natural history and prognosis of heart failure related to Graves disease

Purpose: Graves disease (GD) can both aggravate previous heart disease and cause new heart failure (HF), but large-scale studies are lacking
.

Our purpose is to investigate the incidence, risk factors, and outcomes of GD-related heart failure

Graves disease (GD) can not only aggravate previous heart disease, but also cause new heart failure (HF),

Methods: Retrospective analysis of GD patients admitted from 2009 to 2019
.

According to the left ventricular ejection fraction <50% and Framingham criteria to define reduced ejection fraction (HFrEF), according to the HFA-Pef standard to define ejection fraction retention (HFpEF)

Results: Of the 1371 GD patients, 74 (5.
4%) had heart failure (HFrEF 31 (2.
3%), HFpEF 43 (3.
1%))
.

Atrial fibrillation (HR10.

Figure 1 The median duration of heart failure in GD patients
.

The scatter plot of HFrEF is displayed on the left panel, and HFpEF is displayed on the right panel

Figure 1 The median duration of heart failure in GD patients

Figure 2 Expected and observed incidence of HF
.

The incidence of new HF in Graves disease is significantly higher than the age-matched published rates in the Danish (left group) and UK (right group) populations

Figure 2 Expected and observed incidence of HF

Table 1 Single-factor risk factors associated with GD-related HF, HFrEF and HFpEF

Table 1 Single-factor risk factors associated with GD-related HF, HFrEF and HFpEF

Figure 3 GD-related HFrEF and HFpEF results
.

The logarithmic forest plot shows that the HRs of GD-related HFrEF and GD-free HFrEF (left panel) and GD-related HFpEF and GD-free HFpEF (right panel) are compared with 95% CI

Figure 3 GD-related HFrEF and HFpEF results

New-onset heart failure occurs in 5.

Naser JA, Pislaru S, Stan MN, Lin G, Incidence, risk factors, natural history and outcomes of heart failure in patients with Graves' disease.
Heart 2021 Sep 06

Incidence, risk factors, natural history and outcomes of heart failure in patients with Graves' disease.
Leave a message here