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2022 is not easy, hospital visits and business operations are still deeply affected by the epidemic, and routine medical insurance negotiations have been postponed due to the epidemic, but the achievements of the industry are also remarkable, and here is a review
of some of them.
01 The 20th National Congress was held
01 The 20th National Congress was heldThe 20th National Congress put forward "establishing a birth support policy system" and "implementing a national strategy to actively respond to population aging", and the decline in birth rate and the rise in aging have been highly valued and elevated to the national strategy
.
The number of new births in China that year has decreased from a peak of 17.
86 million in 2016 to 10.
92 million in 2021, a decrease of 39%
in five years.
≥ the proportion of 65-year-olds in the total population increased from 8.
9% in 2010 to 14.
2% in 2021, an increase of 5.
9 percentage points in 11 years, ≥ the number of 65-year-olds increased from 119 million in 2010 to 200 million in 2021, an increase of 81 million in 11 years, an increase of 68%.
On the one hand, the country should reduce the cost of childbirth, parenting and education, and at the same time, the rise of aging will greatly increase the demand
for chronic disease drugs.
Therefore, whether it is research and development, medical insurance or market access, there will be supporting policies
for children's drugs and chronic disease drugs.
The market for children's drugs and drugs for chronic diseases will expand (see Figure 1 for details).
86 million in 2016 to 10.
92 million in 2021, a decrease of 39%
in five years.
02 Centralized procurement: the decline slows down
02 Centralized procurement: the decline slows downUp to now, seven batches of national drug centralized procurement have been carried out, and the price reduction has tended to ease, with the average reduction rate falling from 59% when the 4+7 expansion was extended to 48% of the sixth and seventh batches, and even the reduction rate of the spine national centralized procurement carried out in September this year also made the industry feel much milder (see Figure 2 for details).
03 Innovative drugs
03 Innovative drugsOn July 2, 2021, after CDE issued the "Clinical Value-oriented Guidelines for Clinical R&D of Antitumor Drugs (Draft for Comments)", the valuation of innovative drugs began to decline, and so far there has been little improvement, the overseas and commercialization progress is not too fast, the involution is still the same, and the financing of innovative drugs is still difficult
.
First, financing difficulties
First, financing difficultiesTaking Hong Kong stock Biotech as an example, its operating cash flow has continued to decline in recent years, starting to be negative last year, and still failed to turn negative into positive in the first half of this year (see Figure 3 for details).
).
2.
License
outHit a new high
License outHit a new high
Although Biotech is struggling, innovative achievements continue to emerge, and China's innovative drug license
OUT transaction records are constantly being updated
.
On December 7, Akeso licensed its PD-1/VEGF dual antibody AK112 rights to Summit in the United States, Canada, Europe and Japan
Therapeutics, Akeso will therefore obtain a down payment of 500 million US dollars, and a total transaction amount of up to 5 billion US dollars, refreshing China's innovative drug license
The highest record
for out.
In May this year, Kelun Pharmaceutical's subsidiary, Kelun Pattel, licensed its biomacromolecular tumor project A with independent intellectual property rights to Merck (MSD) for commercial development outside China (see Figure 4 for details).
04 Traditional Chinese Medicine
04 Traditional Chinese Medicine1.
Registration
Registration
On November 11, the State Food and Drug Administration once again solicited public comments on the Special Provisions on the Registration and Administration of Traditional Chinese Medicines (Draft for Comments), emphasizing that "[Safety evaluation requirements that meet the characteristics of traditional Chinese medicines] should comprehensively evaluate the safety of traditional Chinese medicines based on the composition and characteristics of prescriptions, traditional Chinese medicine theory, human experience, clinical trials and necessary non-clinical safety research results, and strengthen the management of the whole life cycle of traditional Chinese medicines".
Second, the formula granules for the record
Second, the formula granules for the recordSince November 1, 2021, after the release of formula granules, relevant enterprises have rushed to file formula granule standards in various provinces, as can be seen from Figure 5, the original national pilot enterprises have maintained their advantages in standard filing, and the filing progress of Yifang, Tianjiang, Kangrentang, Sanjiu and New Green has made rapid
progress.
Hebei's Yiling and Shenwei two traditional Chinese medicine enterprises have become dark horses, their standard filing speed is not inferior to the original national pilot enterprises, in order to sell formula granules, you must first carry out standard filing in the target provincial food and drug administration, the filing speed has become a new watershed for formula granule enterprises (see Figure 5 for details).
05 The epidemic spawned
05 The epidemic spawned1.
Online drug sales
Online drug sales
On December 1, the Measures for the Supervision and Administration of Online Drug Sales (hereinafter referred to as the "Measures") came into force, which will facilitate people's purchase of drugs
.
The Measures also require that "where prescription drugs are sold to individuals through the Internet, the source of prescriptions shall be ensured to be true and reliable, and a real-name system shall be implemented", and "where drugs are sold to individuals, sales certificates
shall be issued in accordance with provisions.
" Sales vouchers can be issued in electronic form, and the sales records of the smallest sales unit of drugs should be clearly retained to ensure traceability", which also provides sufficient protection
for the safety of online drug sales.
2.
County hospitals
County hospitals
On May 6, the State Office of the CPC Central Committee issued the "Opinions on Promoting Urbanization with County Towns as Important Carriers", requiring "promoting the upgrading and transformation of county-level hospitals (including traditional Chinese medicine hospitals), improving the capacity of infectious disease detection, diagnosis and treatment and intensive care and treatment, relying on county-level hospitals to build county-level emergency centers", and "encouraging county-level hospitals and township hospitals to establish a close-knit county-level medical and health community"
。 On December 11, the National Health Commission issued the "Work Plan for Relying on County Medical Communities to Improve the Medical Security Capacity of New Coronary Pneumonia in Rural Areas", proposing that "in order to do a good job in new crown pneumonia medical services in rural areas and ensure the timely treatment of infected people with high risk of severe diseases such as elderly people with underlying diseases, in rural areas, with the county medical community as the carrier, improve the critical treatment capacity of county-level hospitals, give play to the health monitoring role of township hospitals and village clinics, and reduce the rate of severe disease and mortality as much as possible"
.
.
"In order to do a good job in the medical service of new coronary pneumonia in rural areas and ensure the timely treatment of infected people with a high risk of severe disease such as the elderly combined with underlying diseases, in rural areas, the county medical community is used as the carrier to improve the critical treatment capacity of county-level hospitals, and give play to the health monitoring role of township hospitals and village clinics, so as to reduce the rate of severe disease and mortality to the greatest extent"
.
Multiple blockbuster documents have given county hospitals new responsibilities and hopes
.
In the current pandemic, the treatment capacity of county-level hospitals will be severely tested
.
What is the number and layout of county-level hospitals in each province, except for the three municipalities directly under the Central Government of Beijing, Tianjin and Shanghai, which no longer have the administrative structure of counties and county-level cities, and of course, there are no more county-level hospitals, and all provinces and autonomous regions have a certain number of county-level hospitals and county-level city hospitals (hereinafter referred to as "county-level hospitals"
).
Among them, Hebei has the most, in 2021, Hebei Province has a total of 1,452 county hospitals, followed by Henan (1,370), Sichuan (1,231), Shandong (1,128) all have more than 1,000, the above four provinces are all provinces
with large populations and low urbanization rates.
There are also six provinces with more than 700 county hospitals (see Figure 6) including Hunan (970), Yunnan (964), Guizhou (929), Jiangsu (857), Xinjiang (744) and Shanxi (724
).
2022 is about to pass, and it is not innovative drugs that are challenged, but the difficulty of finding a pill of general ibuprofen
.
