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    Home > Active Ingredient News > Digestive System Information > Helicobacter pylori infection can not only lead to stomach cancer, but also related to these diseases!

    Helicobacter pylori infection can not only lead to stomach cancer, but also related to these diseases!

    • Last Update: 2022-02-21
    • Source: Internet
    • Author: User
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    *For medical professionals only to read the reference treatment needs to pay attention to the following 3 points
    .

    Recently, Helicobacter pylori (Hp) has been frequently searched, attracting the attention of the general public
    .

    Yesterday, a 45-year-old woman went to the hospital with abdominal pain and symptoms of weight loss.
    The doctor's test showed that she had a strong positive Hp infection and was found to be progressive gastric cancer
    .

    As soon as the hot search came out, everyone commented on Weibo, saying that Hp infection is terrible! Figure 1 Screenshot of netizen comments Hp infection is the main cause of gastric cancer in China According to the National Cancer Registry, the incidence of gastric cancer in 2015 was second only to lung cancer, ranking second among all malignant tumors; there were 679,100 new cases and 498,000 deaths
    .

    Studies have shown that the incidence of gastric cancer increases significantly with age, and those over 74 years old and infected with H.
    pylori have a higher risk of gastric cancer
    .

    Intestinal-type gastric cancer (accounting for the vast majority of gastric cancers) occurs in the normal gastric mucosa → superficial gastritis → atrophic gastritis → intestinal metaplasia → dysplasia → gastric cancer, which has been recognized
    .

    H.
    pylori infection can cause chronic active gastritis, and also plays an important role in the occurrence and development of gastric mucosal atrophy and intestinal metaplasia.
    Therefore, H.
    pylori infection plays a key role in the occurrence of intestinal-type gastric cancer
    .

    Hp - often "guests" in the stomach, the consequences should not be underestimated.
    According to data, about 1 in every 2 people in China carries Hp, and the infection rate is as high as 40%-60%
    .

    H.
    pylori not only leads to the occurrence of gastric cancer, but also is related to the occurrence and development of many extra-gastrointestinal diseases (Table 1)
    .

    Table 1 Hp infection-related diseases should be eradicated immediately once discovered! "Expert Consensus Opinions on Helicobacter pylori and Gastric Cancer Prevention and Control in China (2019, Shanghai)" clearly pointed out that H.
    pylori eradication can reduce the risk of gastric cancer in China and effectively prevent gastric cancer
    .

    Therefore, no matter whether there are symptoms or not, regardless of gender, as long as they are infected with Hp, people over 18 years old should receive Hp eradication treatment
    .

    "The Sixth National Consensus Report on the Treatment of Helicobacter pylori Infection" (hereinafter referred to as the "Consensus") expounds the treatment of H.
    pylori infection
    .

    (The "Consensus" has not yet been released, but at the 21st National Digestive Disease Academic Conference of the Chinese Medical Association, Professor Lu Hong from the Renji Hospital Affiliated to Shanghai Jiaotong University School of Medicine gave an "updated" spoiler
    .

    ) For initial infection with H.
    pylori and re-treatment, the bismuth quadruple regimen (ie, bismuth + triple regimen, bismuth + PPI + 2 antibiotics) is recommended
    .

    Antibiotic combinations and dosage recommendations are shown in Table 1.
    The selection of the regimen should be based on the local H.
    pylori resistance rate, personal drug application history, weighing the efficacy, drug cost, adverse reactions and its availability
    .

    Table 1 The recommended antibiotic combination and high-dose double-dose regimen of bismuth quadruple regimen refers to the regimen of double-dose proton pump inhibitor combined with ≥3g (administered in 3 or more times) amoxicillin per day, with a course of 14 days.
    A number of domestic and foreign clinical studies have shown that PPI-amoxicillin dual therapy and bismuth quadruple regimen have comparable eradication rates and lower adverse reactions
    .

    Individualized eradication therapy guided by drug susceptibility testing can be performed and recommended under conditions
    .

    Conclusion Although the infection rate of H.
    pylori is high in China, once the adults are eradicated and treated, the chance of reinfection is small
    .

    As long as standardized treatment, attention to dietary hygiene, use of public chopsticks, and regular review, can effectively eradicate H.
    pylori infection and avoid the harm caused by it
    .

    For more exciting content, please watch Professor Chen Shengliang's wonderful answer on Helicobacter pylori treatment from Renji Hospital Affiliated to Shanghai Jiaotong University School of Medicine! References: [1] Expert consensus on Helicobacter pylori eradication and gastric cancer prevention and control in China (2019, Shanghai) [J].
    Chinese Journal of Health Management, 2019, 04: 285-291.
    [2] Zhang Huayang, Liu Qi.
    Research progress on Helicobacter pylori infection and extragastric diseases[J].
    Journal of Intractable Diseases, 2020, 03: 321-324.
    [3] 2021-12-16, The 21st National Academic Conference on Digestive Diseases of the Chinese Medical Association, Shanghai Report of the meeting of Professor Lu Hong from Renji Hospital Affiliated to Jiaotong University School of Medicine.
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