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    Home > Active Ingredient News > Infection > Heparin-binding protein can be used for early diagnosis and prognosis prediction of sepsis

    Heparin-binding protein can be used for early diagnosis and prognosis prediction of sepsis

    • Last Update: 2022-01-25
    • Source: Internet
    • Author: User
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    Introduction The mortality rate of patients with sepsis is high, and it is particularly important to find biomarkers that can help early diagnosis and predict prognosis of sepsis
    .

    Studies have shown that heparin-binding protein (HBP) is closely related to organ dysfunction caused by infection
    .

    The value of HBP in sepsis has not been reported in the literature
    .

    Recently, the journal Shock (IF=3.
    454) reported a prospective study to explore the role of HBP in the early diagnosis and prognosis prediction of sepsis

    .

    Study Overview The study was a prospective, non-interventional, multicenter clinical study
    .

    Adult patients who met the following criteria: (1) core body temperature >38°C or <36°C; (2) heart rate >90 bpm; (3) respiratory rate >20/min and (4) self-reported fever/ Chills
    .

    HBP and procalcitonin (PCT) were detected in all patients within the first hour after admission
    .

    The primary end point was the diagnostic value of HBP for sepsis within the first 72 hours after emergency room admission
    .

    A secondary end point was the prognostic power of HBP for early death, defined as death from any cause recorded in the first 72 hours after emergency room admission; another secondary end point was 28-day mortality
    .

    RESULTS: A total of 400 patients were admitted to the emergency room, of which 371 had HBP and PCT test results
    .

    Results: ➤ HBP was significantly elevated in sepsis patients and positively correlated with PCT and C-reactive protein, absolute neutrophil and monocyte counts, creatinine, bilirubin, and lactate
    .

    ➤ The sensitivity, specificity, positive predictive value and negative predictive value of HBP greater than 19.
    8 ng/ml in the diagnosis of sepsis were 66.
    3%, 44.
    9%, 49.
    3% and 62.
    2%, respectively

    .

    ➤ The sensitivity, specificity, positive predictive value, and negative predictive value of HBP greater than 19.
    8 ng/ml in predicting 72-hour mortality were 100%, 41.
    0%, 4.
    5%, and 100%, respectively

    .

    ➤ HBP and PCT alone did not predict 28-day mortality; when used in combination, the sensitivity, specificity, positive predictive value, and negative predictive value were 44.
    8%, 81.
    8%, 17.
    3%, and 94.
    6%, respectively

    .

    CONCLUSIONS: HBP can be used as a predictive tool for early diagnosis and early mortality risk in sepsis
    .

    However, HBP may change over time, especially in patients with septic shock who require vasopressors
    .

    Yimaitong compiled from: Konstantinos Katsaros, Georgios Renieris, Asimina Safarika, et al.
    Heparin Binding Protein for The Early Diagnosis and Prognosis Of Sepsis In The Emergency Department: The Prompt Multicenter Study.
    hock.
    2021 Dec 14.
    doi: 10.
    1097/SHK .
    0000000000001900.
    Online ahead of print.
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