Heparin-binding protein can be used for early diagnosis and prognosis prediction of sepsis

Introduction The mortality rate of patients with sepsis is high, and it is particularly important to find biomarkers that can help early diagnosis and predict prognosis of sepsis
.

Studies have shown that heparin-binding protein (HBP) is closely related to organ dysfunction caused by infection
.

The value of HBP in sepsis has not been reported in the literature
.

Recently, the journal Shock (IF=3.
454) reported a prospective study to explore the role of HBP in the early diagnosis and prognosis prediction of sepsis
.

Study Overview The study was a prospective, non-interventional, multicenter clinical study
.

Adult patients who met the following criteria: (1) core body temperature >38°C or <36°C; (2) heart rate >90 bpm; (3) respiratory rate >20/min and (4) self-reported fever/ Chills
.

HBP and procalcitonin (PCT) were detected in all patients within the first hour after admission
.

The primary end point was the diagnostic value of HBP for sepsis within the first 72 hours after emergency room admission
.

A secondary end point was the prognostic power of HBP for early death, defined as death from any cause recorded in the first 72 hours after emergency room admission; another secondary end point was 28-day mortality
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RESULTS: A total of 400 patients were admitted to the emergency room, of which 371 had HBP and PCT test results
.

Results: ➤ HBP was significantly elevated in sepsis patients and positively correlated with PCT and C-reactive protein, absolute neutrophil and monocyte counts, creatinine, bilirubin, and lactate
.

➤ The sensitivity, specificity, positive predictive value and negative predictive value of HBP greater than 19.
8 ng/ml in the diagnosis of sepsis were 66.
3%, 44.
9%, 49.
3% and 62.
2%, respectively
.

➤ The sensitivity, specificity, positive predictive value, and negative predictive value of HBP greater than 19.
8 ng/ml in predicting 72-hour mortality were 100%, 41.
0%, 4.
5%, and 100%, respectively
.

➤ HBP and PCT alone did not predict 28-day mortality; when used in combination, the sensitivity, specificity, positive predictive value, and negative predictive value were 44.
8%, 81.
8%, 17.
3%, and 94.
6%, respectively
.

CONCLUSIONS: HBP can be used as a predictive tool for early diagnosis and early mortality risk in sepsis
.

However, HBP may change over time, especially in patients with septic shock who require vasopressors
.

Yimaitong compiled from: Konstantinos Katsaros, Georgios Renieris, Asimina Safarika, et al.
Heparin Binding Protein for The Early Diagnosis and Prognosis Of Sepsis In The Emergency Department: The Prompt Multicenter Study.
hock.
2021 Dec 14.
doi: 10.
1097/SHK .
0000000000001900.
Online ahead of print.