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    Home > Active Ingredient News > Infection > Hepatitis outbreaks in children in Europe are concentrated, experts say the cause is unknown, and it has a certain relationship with the new crown epidemic

    Hepatitis outbreaks in children in Europe are concentrated, experts say the cause is unknown, and it has a certain relationship with the new crown epidemic

    • Last Update: 2022-05-21
    • Source: Internet
    • Author: User
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    Guided reading

    Guided reading

    The anxiety in April seems to never stop
    .

    The anxiety in April seems to never stop
    .

    On April 15, the World Health Organization (WHO) announced that dozens of children in the UK had developed acute hepatitis symptoms for unknown reasons
    .
    Since then, the number of severe acute hepatitis cases has soared from 10 cases on the 5th to 74 cases on the 8th, and then to 114 cases on April 23rd.
    It is inevitable to ask one question: what happened?

    On April 15, the World Health Organization (WHO) announced that dozens of children in the UK had developed acute hepatitis symptoms for unknown reasons
    .
    Since then, the number of severe acute hepatitis cases has soared from 10 cases on the 5th to 74 cases on the 8th, and then to 114 cases on April 23rd.
    It is inevitable to ask one question: what happened?

    Not only the United Kingdom, Spain, the United States and other 12 countries have also successively reported unexplained cases of childhood hepatitis.
    Is it a common virus that causes hepatitis, or is it related to the new coronavirus?

    Not only the United Kingdom, Spain, the United States and other 12 countries have also successively reported unexplained cases of childhood hepatitis.
    Is it a common virus that causes hepatitis, or is it related to the new coronavirus?

    Let’s start with the data as of April 23
    .

    On April 23, a total of 169 cases of childhood hepatitis of unknown etiology were reported in 12 countries around the world (mostly in Europe and the United States), of which 114 were from the United Kingdom
    .
    So far, the patients ranged in age from 1 to 16 years old, 17 of them required liver transplants, and at least one child died

    .

    In the UK, where the situation is the most critical, 74 of the 114 hepatitis cases were detected with adenovirus; 20 with new coronavirus; and 19 with both new coronavirus and adenovirus
    .

    What causes hepatitis

    What causes hepatitis

    Distribution of cases of acute severe hepatitis of unknown cause by country as of April 23, 2022
    .
    (Source: WHO)

    Based on the current situation, the clinical syndrome of these confirmed cases is acute hepatitis with markedly elevated liver enzymes
    .
    The vast majority of patients developed gastrointestinal symptoms such as abdominal pain, diarrhea, and vomiting, but most did not have fever

    .

    The common viruses that cause acute viral hepatitis (hepatitis A, B, C, D, and E) were not detected in these cases, so common viruses can be ruled out first
    .

    In terms of vaccines, the vast majority of sick children have not been vaccinated against the new crown, and this acute hepatitis storm has nothing to do with the so-called side effects of the new crown vaccine
    .

    In addition, international travel or links with other countries are not supported by evidence and cannot be determined for the time being
    .

    So, could the adenovirus, which accounts for the highest proportion of cases, be the culprit?

    Is there a possibility of co-infection between the new coronavirus and adenovirus?

    Is there a possibility of co-infection between the new coronavirus and adenovirus?

    Adenovirus is actually a relatively common virus.
    Adenovirus hepatitis mostly occurs in children and adults with low immunity, but the probability of developing severe acute hepatitis is generally low.
    This large-scale outbreak is caused by the mutation of adenovirus.
    Fulminant adenoviral hepatitis is still affected by other factors, and more in-depth case studies are needed

    .

    Dr Thassos Gramaticopoulos, a consultant paediatric hepatologist at King's College Hospital in London, pointed out that the severe response to adenovirus in children may be due to a lack of "social interaction" during the lockdown
    .
    In layman's terms, children do not go out much because of the new crown epidemic, and they are rarely exposed to common pathogens, resulting in weak immunity to adenovirus

    .

    There are many other inferences, but the real reason needs further study
    .
    Could reduced circulating levels of adenovirus during the COVID-19 pandemic lead to increased susceptibility in young children? Is there a new mutation in adenovirus? Is there a possibility of co-infection between the new coronavirus and adenovirus?

    WHO recommends that countries conduct further work to determine the cause of the disease to further refine control and prevention measures
    .

    As Covid-19 rages on, we must take the coronavirus seriously as a possible cause of unusual cases
    .
    The world situation is always changing, and there may be more unknown cases in the future.
    Corresponding prevention and control measures depend on the coordination of relevant departments to follow up in a timely manner to protect the public

    .

    References

    References

    1.
    WHO: 169 cases of childhood hepatitis of unknown etiology reported worldwide, 1 death

    1.
    WHO: 169 cases of childhood hepatitis of unknown etiology reported worldwide, 1 death

    https://baijiahao.
    baidu.
    com/s?
    id=1730952869127099411

    https://baijiahao.
    baidu.
    com/s?
    id=1730952869127099411

    2.
    Acute hepatitis in children with unknown outbreaks in the United Kingdom and the United States may be related to adenovirus type 41, which may belong to fulminant adenovirus hepatitis

    2.
    Acute hepatitis in children with unknown outbreaks in the United Kingdom and the United States may be related to adenovirus type 41, which may belong to fulminant adenovirus hepatitis

    https:// id=9049e24509b7

    https:// id=9049e24509b7

    3.
    https:// https:// https:// https:// Unexplained childhood hepatitis broke out in Europe and the United States, and 8 severe patients in the UK received liver transplantation.
    British health department: Adenovirus infection is highly likely

    5.
    Unexplained childhood hepatitis broke out in Europe and the United States, and 8 severe patients in the UK received liver transplantation.
    British health department: Adenovirus infection is highly likely

    http://news.
    chengdu.
    cn/2022/0424/2257749.
    shtml

    http://news.
    chengdu.
    cn/2022/0424/2257749.
    shtml

    6.
    There has been 1 death in children with unexplained hepatitis, and adenovirus infection has attracted attention

    6.
    There has been 1 death in children with unexplained hepatitis, and adenovirus infection has attracted attention

    https://baijiahao.
    baidu.
    com/s?
    id=1730967652465558214&wfr=spider&for=pc

    https://baijiahao.
    baidu.
    com/s?
    id=1730967652465558214&wfr=spider&for=pc


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