Hepatobiliary Surg Nutr: Gene mutation characteristics of Chinese liver cancer patients!

Hepatocellular carcinoma (HCC) is the sixth most common cancer in the world and the fourth most common cause of cancer-related death.

This study aims to analyze the genetic characteristics of HCC patients in China.

A total of 165 HCC patients were recruited, including 146 men and 19 women.

Mutation map

Mutation map

A total of 1,004 genetic variants were detected in 258 genes in 168 HCC tissues.

The most common mutant genes are TP53, TERT, CTNNB1, AXIN1, RB1, TSC2, CCND1, ARID1A, and FGF19

Compared to wild type patients, patients carrying mutations in TP53 Edmondson III-IV stage and a micro- vessel ratio infiltration significantly higher (p <0.

In stage Edmondson III-IV and micro patients carrying mutations in TP53 vessel ratio significantly higher infiltration vessel in the patient TERT mutations, tumor invasion of the liver capsule proportion was significantly higher in patients with mutations in CTNNB1, Edmondson III level, The proportion of alpha-fetoprotein (AFP) <25 μmg/L and no history of hepatitis B is significantly increased.

TP53 mutation is independently associated with microvascular invasion and Edmondson grade III-IV TERT mutation is independently associated with liver capsule tumor invasion CTNNB1 mutation is independently associated with AFP

In summary, the most common mutated genes in Chinese HCC patients are TP53, TERT and CTNNB1.

The most common mutated genes in Chinese HCC patients are TP53, TERT and CTNNB1.

Original source:

Wang Shuo,Shi Huasheng,Liu Tao et al.

org/10.
21037/hbsn.
2019.
09.
17" target="_blank" rel="noopener">Mutation profile and its correlation with clinicopathology in Chinese hepatocellular carcinoma patients in this message