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Hepatol Int: A prospective study evaluating the efficacy of TACE using lipiodol alone versus TACE using lipiodol combined with degradable starch microspheres (DSM) in the treatment of hepatocellular carcinoma

 Last Update: 2021-07-31
 Source: Internet
 Author: User

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Transarterial chemoembolization (TACE) is a commonly used treatment for hepatocellular carcinoma (HCC)
.

Recently, Hepatology International published a prospective study to evaluate the efficacy of lipiodol alone versus lipiodol combined with degradable starch microspheres (DSM) in BCLC-B HCC patients

Sixty-two patients met the inclusion criteria, but 61 patients were eventually included.
Randomized treatment was assigned to the TACE-only lipiodol group (group 1) and the TACE-use lipiodol combined with DSM group (group 2).
There were 30 and 31 patients, respectively
.

Research Overview

In the overall population, the average tumor volume was reduced by 21.
45% (±62.
34%)
.

The average tumor volume reduction was 19.

For the mRECIST standard assessment, patients in group 2 benefited significantly from patients in group 1 (p = 0.
010)
.

Among them, group 1 was compared with group 2.

For the mRECIST standard assessment, patients in group 2 benefited significantly from patients in group 1 (p = 0.

Efficacy evaluation

In 50 patients, there were no treatment-related complications
.

Grade 1 complications occurred in 9 patients, which were nausea or fever after intervention (14.

The median OS of the entire cohort was 24.
61 months (range 1 54 months)
.

The median OS of the TACE lipiodol group alone was 26.

In the survival analysis of the study cohort, the median OS of the study cohort was 32.
5 months (95% CI: 26.
6–38.
4), the median OS of group 1 was 29.
4 months (95% CI 21.
7–37.
1), and the median OS of group 2 It was 33.
4 months (95% CI 25.
5–41.
4)
.

In the survival analysis of the study cohort, the median OS of the study cohort was 32.

subsistence analysis

Survival analysis Survival analysis

Cox regression analysis showed that low baseline AFP values (p = 0.
002), small tumor volume and diameter (p = 0.
046 and p = 0.
005) were associated with better survival
.

In summary, for BCLC-B HCC patients, adding degradable starch microspheres (DSM) to the traditional TACE-lipiodol can improve tumor response (according to mRECIST criteria), but the prognosis is not beneficial
.

For BCLC-B HCC patients, adding degradable starch microspheres (DSM) on the basis of traditional TACE-lipiodol can improve tumor response (according to mRECIST criteria), but the prognosis is not beneficial
.
For BCLC-B HCC patients, adding degradable starch microspheres (DSM) on the basis of traditional TACE-lipiodol can improve tumor response (according to mRECIST criteria), but the prognosis is not beneficial
.

Original source:

TJ Vogl, MC Langenbach, R Hammerstingl, et al.
Evaluation of two different transarterial chemoembolization protocols using Lipiodol and degradable starch microspheres in therapy of hepatocellular carcinoma: a prospective trial.
Hepatol Int.
2021 May 27.
doi: 10.
1007/s12072-021- 10193-8.

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