Hepatology: A link between the concentration of circulating steroid hormones in post-menophoty women and liver cancer.

BACKGROUND: In almost all countries, the incidence of liver cancer (LC) is 100%-200% higher in men than in women.
, however, this difference is mainly driven by hepatocellular carcinoma (HCC), which accounts for 75 per cent of liver cancer cases, endo-liver bile tube cancer (ICC) for 12 per cent of cases, and only 30 per cent for men.
this study assumes that hormones are the basis for gender differences, and the researchers determined whether they were associated with LC risk by investigating pre-diagnosis levels of circulatory hormones and sex hormone-binding globulin (SHBG).
methods and results: The researchers used gas chromatography/series mass spectrometry and competitive electrochemical luminescent immunoanalysis to quantify 7 sex steroid and sex hormone binding globulins (SHBG) from 191 post-menoptostrual female LC patients (HCC, n s 83; ICC, n s 56) and 426 control group baseline serum/plasma samples, respectively.
then performed a statistical analysis of hormone levels and the incidence of liver cancer in all patients.
results: The results showed that double the concentration of 4-andthyl dycotones (4-dycotones) reduced the risk of LC by 50% (OR s 0.50; 95% CI s 0.30-0.82), while SHBG elevation increased the risk by 31% (OR s 1.31; 95% CI s 1.05-1.63).
, esodiol doubles are associated with a 40% increase in ICC risk (OR s 1.40; 95% CI s 1.05-1.89), but not HCC (OR s 1.12; 95% CI s 0.81-1.54).
chart: Steroid hormone metabolism pathway conclusions: This study provides evidence that higher levels of 4-dyrosterone may be associated with lower SHBG and higher LC risk in women, so the female steroid hormone esolycol may be associated with increased ICC risk.
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