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    Home > Active Ingredient News > Digestive System Information > Hepatology: Serum vitamin D concentrations associated with survival rates of liver cell carcinoma

    Hepatology: Serum vitamin D concentrations associated with survival rates of liver cell carcinoma

    • Last Update: 2020-06-23
    • Source: Internet
    • Author: User
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    Background and objectives: Free and biousable 25-hydroxy vitamin D is two different measures of vitamin DIt is not clear whether free 25OHD or biousable 25OHD is associated with the prognosis of hepatocellular carcinoma (HCC)The purpose of this study is to test the assumption that bioavailability of 25OHD may be a better serum biomarker in vitamin D state in the context of HCC survival than total 25OHD: This study included a new diagnosis of liver cancer in Guangdong Province from September 2013 to April 2017, with 1,031 previously untreated cases of HCCThe total serum 25OHD level was measured by electrochemical luminescence immunoassayThe serum-free 25OHD level was measured using a two-step enzyme-linked immunosorption assayUsing previously verified equations, bioavailable levels of 25OHD were calculated by measured free 25OHD and albuminThe main results are liver cancer specificity (LCSS) and total survival (OS)The Cox Scale Risk Model is performed to calculate the multivariate risk ratio (HRs) and the 95% confidence interval (CIs)results: 430 patients died, including 393 deaths from HCC, during an average of 726 days of follow-upIn multivariate analysis, higher levels of bioavailability of 25OHD were significantly correlated with better survival rates, but not with non-clinical and clinical prognostic factors(including serum C reactive proteins, Clinical liver cancer stages and cancer treatment in Barcelona)The multivariate HR between the highest quartile of bioavailability level 25OHD and the lowest quartile is 0.69 (95% CI: 0.51, 0.93;conclusion: The higher content of 25OHD was independently related to survival improvement in the HCC queue in the population, indicating that the bioavailability of 25OHD had potential uses in hCC prognosis
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